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Clinical Trial
. 2024 Oct 10;391(14):1360-1362.
doi: 10.1056/NEJMc2408121. Epub 2024 Sep 14.

Pembrolizumab in HER2-Positive Gastric Cancer

Yelena Y Janjigian  1 , Akihito Kawazoe  2 , Yuxian Bai  3 , Jianming Xu  4 , Sara Lonardi  5 , Jean Phillipe Metges  6 , Patricio Yañez  7 , Lucjan S Wyrwicz  8 , Lin Shen  9 , Yuriy Ostapenko  10 , Mehmet Bilici  11 , Hyun Cheol Chung  12 , Kohei Shitara  2 , Shukui Qin  13 , Eric Van Cutsem  14 , Josep Tabernero  15 , Suxia Luo  16 , Mauricio Mahave  17 , Yong Tang  18 , Maeve Lowery  19 , Maria M F Monteiro  20 , Linzhi Xu  21 , Chie-Schin Shih  21 , Kanu P Sharan  21 , Pooja Bhagia  21 , Sun Young Rha  12
Affiliations
Clinical Trial

Pembrolizumab in HER2-Positive Gastric Cancer

Yelena Y Janjigian et al. N Engl J Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Kaplan-Meier estimates of overall survival in all participants (A) and in participants with PD-L1 CPS ≥1 tumors (B) at final analysis.
See this image and copyright information in PMC

Comment on

  • The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer.
    Janjigian YY, Kawazoe A, Yañez P, Li N, Lonardi S, Kolesnik O, Barajas O, Bai Y, Shen L, Tang Y, Wyrwicz LS, Xu J, Shitara K, Qin S, Van Cutsem E, Tabernero J, Li L, Shah S, Bhagia P, Chung HC. Janjigian YY, et al. Nature. 2021 Dec;600(7890):727-730. doi: 10.1038/s41586-021-04161-3. Epub 2021 Dec 15. Nature. 2021. PMID: 34912120 Free PMC article. Clinical Trial.

References

    1. Janjigian YY, Kawazoe A, Yanez P, et al. The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer. Nature 2021;600(7890):727–730. DOI: 10.1038/s41586-021-04161-3. - DOI - PMC - PubMed
    1. Janjigian YY, Kawazoe A, Bai Y, et al. Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase 3 KEYNOTE-811 randomised placebo-controlled trial. Lancet (London, England) 2023;402(10418):2197–2208. (In eng). DOI: 10.1016/s0140-6736(23)02033-0. - DOI - PubMed

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