Temocillin concentrations in human tissues

Abstract

67 samples of 15 different tissues were obtained from 26 patients who were given an intravenous bolus dose of temocillin approximately 3 to 4 hours prior to surgery. 50 tissue samples were obtained from 19 patients who received 1g temocillin and 17 tissue samples were obtained from 7 patients who received 2g temocillin. The majority of tissue samples were removed 3 to 4 hours after administration of the drug and, at this time, group mean serum concentrations were 53.5 mg/L (1g doses) and 117.3 mg/L (2g doses). Mean tissue concentrations of 8 to 10 mg/kg were seen in muscle, liver and skin samples after 1g doses, and 18, 34 and 9 mg/kg, respectively, after 2g doses. Temocillin concentrations seen in the gallbladder were considerably higher than those in other tissues.