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Review
. 2025 Mar;480(3):1481-1493.
doi: 10.1007/s11010-024-05108-8. Epub 2024 Sep 16.

Synergistic potential of stem cells and microfluidics in regenerative medicine

Resmi Rajalekshmi  1 , Devendra K Agrawal  2
Affiliations
Review

Synergistic potential of stem cells and microfluidics in regenerative medicine

Resmi Rajalekshmi et al. Mol Cell Biochem. 2025 Mar.

Abstract

Regenerative medicine has immense potential to revolutionize healthcare by using regenerative capabilities of stem cells. Microfluidics, a cutting-edge technology, offers precise control over cellular microenvironments. The integration of these two fields provides a deep understanding of stem cell behavior and enables the development of advanced therapeutic strategies. This critical review explores the use of microfluidic systems to culture and differentiate stem cells with precision. We examined the use of microfluidic platforms for controlled nutrient supply, mechanical stimuli, and real-time monitoring, providing an unprecedented level of detail in studying cellular responses. The convergence of stem cells and microfluidics holds immense promise for tissue repair, regeneration, and personalized medicine. It offers a unique opportunity to revolutionize the approach to regenerative medicine, facilitating the development of advanced therapeutic strategies and enhancing healthcare outcomes.

Keywords: Biomedical devices; Microfluidics; Regenerative medicine; Stem cells; Tissue repair.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Consent for publication: Both authors have read the manuscript and consented for publication.

Figures

Fig. 1
Fig. 1
Different types of adult stem cells and their differentiation potential
Fig. 2
Fig. 2
Schematic representation of the microfluidic chip
Fig. 3
Fig. 3
Microfluidic platforms
Fig. 4
Fig. 4
Regulation of stem cell differentiation in microfluidic device
See this image and copyright information in PMC

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