Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2024 Nov;43(11):2191-2199.
doi: 10.1007/s10096-024-04936-2. Epub 2024 Sep 16.

Risk factors for infection after carbapenem-resistant Acinetobacter baumannii colonization

Maddalena Peghin  1 , Filippo Givone  2 , Maria de Martino  3 , Raja Waqar Ali  2 , Elena Graziano  2 , Miriam Isola  3 , Paolo Antonio Grossi  2
Affiliations
Observational Study

Risk factors for infection after carbapenem-resistant Acinetobacter baumannii colonization

Maddalena Peghin et al. Eur J Clin Microbiol Infect Dis. 2024 Nov.

Abstract

Purpose: Predicting infection risk in carbapenem-resistant Acinetobacter baumannii (CRAB) colonized patients may help in improving timely appropriate antibiotic therapy. This study aims to explore risk factors for developing infections in hospitalized patients with previous CRAB colonization.

Methods: We performed an observational retrospective cohort study at ASST Sette Laghi-Varese Hospital between January 2020 and December 2022. All consecutive adult (> 18 years old) hospitalized patients with documented colonization by CRAB at any anatomical site or with CRAB infections preceded by CRAB colonization were included. Univariate and multivariate analyses were performed to investigate infection risk factors.

Results: Overall, 144 patients were included in the study: 104 colonized only and 40 infected patients. Colonization and infection rates significantly changed over the years (2020-2022, p < 0.001). The incidence of infections in CRAB carriers was 27.8% (40/144). Median time from colonization to infection was 4 days (IQR 1-8.5). Overall, inhospital mortality was 32.7% and 55.0% in colonized only and infected patients, respectively. At the multivariable logistic regression cardiovascular disease (OR 5.83, 95% CI 1.12-30.43, p = 0.037), COVID-19 (OR 3.72, 95% CI 1.16-11.91, p = 0.027) and intensive care unit (ICU) admission (OR 8.83, 95% CI 2.94-26.51, p < 0.001) were risk factors independently associated with cardiovascular disease CRAB infection after colonization.

Conclusions: We observed an increased infection risk in patients colonized with CRAB with cardiovascular disease, COVID-19 and admitted in ICU setting. Additional evidence is needed to identify predictors of infection in colonized patients.

Keywords: Acinetobacter baumannii; Carbapenem-resistant Acinetobacter baumannii; Colonization; Multidrug-Resistant.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of CRAB colonized ad infected patients included in the study (2020–2022)
See this image and copyright information in PMC

References

    1. https://www.who.int/publications/i/item/9789240093461
    1. Boccabella L, Palma EG, Abenavoli L, Scarlata GGM, Boni M, Ianiro G et al (2024) Post-coronavirus Disease 2019 Pandemic Antimicrobial Resistance. Antibiot (Basel). 13(3) - PMC - PubMed
    1. Russo A, Gavaruzzi F, Ceccarelli G, Borrazzo C, Oliva A, Alessandri F et al (2022) Multidrug-resistant Acinetobacter baumannii infections in COVID-19 patients hospitalized in intensive care unit. Infection 50(1):83–92 - PMC - PubMed
    1. Smith RM, Lautenbach E, Omulo S, Araos R, Call DR, Kumar GCP et al (2021) Human colonization with Multidrug-resistant organisms: getting to the bottom of Antibiotic Resistance. Open Forum Infect Dis 8(11):ofab531 - PMC - PubMed
    1. Willems RPJ, van Dijk K, Vehreschild M, Biehl LM, Ket JCF, Remmelzwaal S et al (2023) Incidence of infection with multidrug-resistant Gram-negative bacteria and Vancomycin-resistant enterococci in carriers: a systematic review and meta-regression analysis. Lancet Infect Dis 23(6):719–731 - PubMed

Publication types

MeSH terms

LinkOut - more resources