Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 28:55:101491.
doi: 10.1016/j.gore.2024.101491. eCollection 2024 Oct.

Ureteral stenting in patients with locally advanced cervical cancer: Predictors of low success rate

Kaleab Habtemichael Gebreselassie  1 , Tadele Aweke Adamu  2 , Andualem Deneke Beyene  3
Affiliations

Ureteral stenting in patients with locally advanced cervical cancer: Predictors of low success rate

Kaleab Habtemichael Gebreselassie et al. Gynecol Oncol Rep. .

Abstract

Objective: Cervical cancer is the leading gynecologic malignancy in Ethiopia. The diagnosis is often delayed and many patients present with locally advanced disease. Involvement of the ureters with or without the development of hydroureteronephrosis is a common finding. Ureteral stent placement is a modality utilized to relieve an established obstruction (therapeutic) or to prevent its early occurrence (prophylactic). However, the procedure may not be successful in all patients. The objective of this study is to assess the factors associated with low success rate of ureteral stenting in these patients with locally advanced disease.

Methods: This is a hospital based cross-sectional study of patients diagnosed with locally advanced cervical cancer for whom a retrograde ureteral stent placement is attempted from January 2019 to March 2020. Data of 175 patients were retrieved by a retrospective chart review and analyzed for factors associated with low procedural success.

Results: Socio-demographic data were similar between patients regardless of procedural success. The overall success rate of stenting was 54.2 %. In the prophylactic group (with no hydronephrosis and normal creatinine) success rate was 94 % and in the therapeutic group 42.6 %. Logistic regression analysis showed that bilateral hydronephrosis and increased serum creatinine were indicators of significant ureteral obstruction and were predictors of stent placement failure.

Conclusion: Increased serum creatinine and presence of hydronephrosis are risk factors for failed ureteral stenting. For these patients, other options of urinary diversion such as percutaneous nephrostomy should be considered from the outset.

Keywords: Cervical cancer; Hydronephrosis; Locally advanced; Serum creatinine; Ureteral obstruction; Ureteral stenting.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Age distribution of patients with locally advanced cervical cancer who underwent stenting procedure.
Fig. 2
Fig. 2
Timing of initial hospital visist after onset symptom in patients with locally advanced cervical cancer.
See this image and copyright information in PMC

References

    1. Amado G., Weldegebreal F., Birhanu S., Dessie Y. Cervical cancer screening practices and its associated factors among females of reproductive age in Durame town, Southern Ethiopia. PLoS One. 2022;17(12) doi: 10.1371/journal.pone.0279870. - DOI - PMC - PubMed
    1. Chung S.Y., Stein R.J., Landsittel D., Davies B.J., Cuellar D.C., Hrebinko R.L., Tarin T., Averch T.D. 15-year experience with the management of extrinsic ureteral obstruction with indwelling ureteral stents. J. Urol. 2004;172(2):592–595. doi: 10.1097/01.ju.0000130510.28768.f5. - DOI - PubMed
    1. Derek L., Matthew Z. American Urological Association (AUA) News; 2023. Update on the Management of Malignant Ureteral Obstruction.
    1. Dhani F.K., Daryanto B., Seputra K.P. Survival outcome of urinary diversion in advanced cervical Cancer patients with Hydronephrosis. Asian Pac. J. Cancer Prev. 2023;24(8):2641. doi: 10.31557/apjcp.2023.24.8.2641. - DOI - PMC - PubMed
    1. Disease prevention and control directorate. Federal Ministry of Health of Ethiopia, National cancer control plan 2016–2020, October 2015.

LinkOut - more resources