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Review
. 2024 Aug 17;16(8):e67054.
doi: 10.7759/cureus.67054. eCollection 2024 Aug.

Acute Phase Peyronie's Disease: Where Do We Stand?

Konstantinos Douroumis  1 , Konstantinos Kotrotsios  1 , Panagiotis Katsikatsos  1 , Napoleon Moulavasilis  1 , Evangelos Fragkiadis  1 , Dionysios Mitropoulos  1 , Ioannis Adamakis  1
Affiliations
Review

Acute Phase Peyronie's Disease: Where Do We Stand?

Konstantinos Douroumis et al. Cureus. .

Abstract

Peyronie's disease (PD) is a common benign condition characterized by superficial fibrosis and scar formation at the tunica albuginea of the penis, eventually leading to penile curvature. It is believed that penile micro-traumas during intercourse and subsequent activation of inflammatory processes constitute the pathogenetic basis of the disease. Routinely, PD is divided into acute and chronic phases, with pain during erection or flaccid state being the hallmark of the former. Surgical intervention should be avoided during the acute phase, as the risk of recurrence or progression of penile deformity during this stage might affect the optimal outcomes of the procedure. During this stage, many conservative treatment options have been suggested, including oral, topical, and intralesional therapies, extracorporeal shock wave therapy (ESWT), and penile traction therapy (PTT). Currently, the optimal treatment consists of a combined treatment strategy with phosphodiesterase type 5 inhibitors (PDE5Is), ESWT for pain management, PTT, and intralesional therapies. Large, well-designed randomized controlled trials (RCTs) are necessary to further elucidate the most efficient treatment option for acute phase PD.

Keywords: acute phase; andrology; male sexual health; penile curvature; peyronie disease.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. A PRISMA flow diagram summarizing the selection process [57].
MEDLINE: Medical Literature Analysis and Retrieval System Online; Embase: Excerpta Medica database; CENTRAL: Cochrane Controlled Register of Trials; PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses
See this image and copyright information in PMC

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