Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Mar 14;25(2):127-136.
doi: 10.1136/pn-2024-004241.

Genetic testing in dementia

Antoinette O'Connor  1   2 , Natalie S Ryan  3   4 , Christopher R S Belder  3   5 , David S Lynch  6 , Nayana Lahiri  7 , Henry Houlden  6 , Jonathan D Rohrer  3   4 , Nick C Fox  3   4 , Sean O'Dowd  8   9   10
Affiliations
Review

Genetic testing in dementia

Antoinette O'Connor et al. Pract Neurol. .

Abstract

There is growing public awareness and concern regarding dementia risk. In addition, genetic testing is increasingly accessible and is at the point of being integrated into routine clinical practice. As a result, there is a pressing need for treating clinicians to have the appropriate knowledge base to request and consent for diagnostic genetic testing in cognitive clinics. We outline our approach to genetic testing in patients with Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies and vascular cognitive impairment. We discuss when to consider testing, the consenting process, and the interpretation and communication of genetic test results.

Keywords: ALZHEIMER-S DISEASE; DEMENTIA; GENETICS.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.