CAR T-cell-associated neurotoxicity: A comprehensive review

Abstract

Chimeric antigen receptor T-cell (CAR T-cell) therapies have emerged as a promising treatment modality for several malignancies, particularly haematological malignancies, by inducing robust antitumour responses. However, CAR T-cell therapies are associated with a spectrum of adverse events, including neurological complications. We here provide a review of neurological adverse events observed in patients undergoing CAR T-cell therapy, focusing on their incidence, clinical manifestations, underlying mechanisms and potential management strategies.

Keywords: Brain; CAR T-cell therapy; Haematological malignancies; Immune effector cell-associated neurotoxicity syndrome (ICANS); Neurotoxicity; Toxicity.