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. 2024 Sep 17;24(1):317.
doi: 10.1186/s12876-024-03412-7.

Impact of prior SARS-CoV-2 infection on postoperative recovery in patients with hepatocellular carcinoma resection

Dan Fang  1 , Lei Wu  2 , Bi-Ling Gan  1 , Chu-Lin Guo  3 , Zhi-Hong Chen  4 , Shun-An Zhou  1 , Fan Wu  4 , Lian- QunXu  1 , Zhen-Rong Chen  1 , Ning Shi  5 , Hao-Sheng Jin  6
Affiliations

Impact of prior SARS-CoV-2 infection on postoperative recovery in patients with hepatocellular carcinoma resection

Dan Fang et al. BMC Gastroenterol. .

Abstract

Background: The impact of prior SARS-CoV-2 infection on postoperative recovery of patients who underwent liver resection for hepatocellular carcinoma (HCC) remains uncertain given the lack of sufficient evidence.

Aim: To investigate the impact of prior SARS-CoV-2 infection on postoperative recovery of patients who underwent liver resection for hepatocellular carcinoma (HCC).

Methods: Patients who were pathologically diagnosed with HCC and underwent elective partial hepatectomy in Guangdong Provincial People's Hospital between January 2022 and April 2023 were enrolled in this retrospective cohort study. The patients were divided into two groups based on their history of SARS-CoV-2 infection. Rehabilitation parameters, including postoperative liver function, incidence of complications, and hospitalization expenses, were compared between the two groups. Propensity score matching (PSM) was performed to reduce confounding bias.

Results: We included 172 patients (58 with and 114 without prior SARS-CoV-2 infection) who underwent liver resection for HCC. No significant differences in the rehabilitation parameters were observed between the two groups. After PSM, 58 patients were selected from each group to form the new comparative groups. Similar results were obtained within the population after PSM.

Conclusion: Prior SARS-CoV-2 infection does not appear to affect postoperative rehabilitation, including liver function, postoperative complications, or hospitalization expenses among patients with HCC after elective partial hepatectomy.

Keywords: Hepatocellular carcinoma; Liver function; Partial hepatectomy; Postoperative complications; SARS-CoV-2 infection.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The patient selection process
See this image and copyright information in PMC

References

    1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F, Global Cancer S. 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660. Epub 2021 Feb 4. PMID: 33538338. - PubMed
    1. Shang HT, Bao JH, Zhang XB, Wang HB, Zhang HT, Li ZL. Comparison of clinical efficacy and complications between laparoscopic partial and open partial hepatectomy for liver carcinoma: a Meta-analysis. J Laparoendosc Adv Surg Tech A. 2019;29(2):225–32. 10.1089/lap.2018.0346. Epub 2019 Jan 17. PMID: 30653396. - DOI - PubMed
    1. Rastogi A. An approach to grossing of hepatectomy specimens. Indian J Pathol Microbiol. 2021;64(Supplement):S121-S126. 10.4103/IJPM.IJPM_870_20. PMID: 34135153. - PubMed
    1. Abdelmalek MF. Nonalcoholic fatty liver disease: another leap forward. Nat Rev Gastroenterol Hepatol. 2021;18(2):85–6. 10.1038/s41575-020-00406-0. PMID: 33420415; PMCID: PMC7791336. - DOI - PMC - PubMed
    1. Hariyanto TI, Jodhinata C, Halim DA, Kurniawan A. Association between viral hepatitis and increased risk of severe coronavirus disease 2019 (COVID-19) outcome: a systematic review and meta-analysis. Gastroenterol Hepatol Bed Bench. 2022 Winter;15(1):9–14. PMID: 35611257; PMCID: PMC9123631. - PMC - PubMed

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