Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 5;28(5):535.
doi: 10.3892/ol.2024.14668. eCollection 2024 Nov.

Incidence and pattern of second primary cancer in patients diagnosed with primary cancer

Affiliations

Incidence and pattern of second primary cancer in patients diagnosed with primary cancer

Jong Jin Sung et al. Oncol Lett. .

Abstract

The long survival of patients with primary cancer increases the chance of such patients developing second primary cancer (SPC). The development of SPC in cancer survivors exerts a large psychological, social and economic burden on patients and their families. The aim of the present study was to assess the risk of cancer survivors developing SPC. The study included patients who had been diagnosed with a first primary cancer in five organs (stomach, colorectum, lung, breast and thyroid), which are the five most common sites of cancer in patients from Korea, at the regional cancer center in Jeonbuk National University Hospital between January 2007 and December 2009. The standardized incidence ratio (SIR) of SPC according to sex and site was calculated from 5,209 patients who were followed up to September 2017. General incidence was acquired from the National Cancer Registry of Republic of Korea. SPC occurred in 6.2% (323/5,209) of patients, and the incidence of SPC among the five major types of cancer was in the order of breast (8.8%, 46/524), colorectum (8.6%, 86/1,003), gastric (6.6%, 89/1,358), thyroid (4.7%, 67/1,437) and lung cancer (3.9%, 35/887). When all SPC sites were included, the SIRs of SPC in patients with colorectal cancer and breast cancer were >1.0 (1.21 and 1.66, respectively). Breast cancer and thyroid cancer exhibited a high site relationship (P<0.05), and colorectal cancer had a high site relationship with gastric cancer (P<0.05). The present study analyzed the incidence and pattern of SPC in patients with cancer who were diagnosed with primary carcinoma in five organs. The results of the study may be useful for effective follow-up and early detection of SPC in patients with cancer.

Keywords: breast cancer; colorectal cancer; lung cancer; second primary cancer; stomach cancer; thyroid cancer.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Bugher JC. The probability of the chance occurrence of multiple malignant neoplasms. Am J Cancer. 1934;21:809–824.
    1. Travis LB, Demark Wahnefried W, Allan JM, Wood ME, Ng AK. Aetiology, genetics and prevention of secondary neoplasms in adult cancer survivors. Nat Rev Clin Oncol. 2013;10:289–301. doi: 10.1038/nrclinonc.2013.41. - DOI - PubMed
    1. Sung H, Hyun N, Leach CR, Yabroff KR, Jemal A. Association of first primary cancer with risk of subsequent primary cancer among survivors of adult-onset cancers in the United States. JAMA. 2020;324:2521–2535. doi: 10.1001/jama.2020.23130. - DOI - PMC - PubMed
    1. Pacheco-Figueiredo L, Antunes L, Bento MJ, Lunet N. Incidence of second primary cancers in North Portugal-a population-based study. J Cancer Surviv. 2016;10:142–152. doi: 10.1007/s11764-015-0460-0. - DOI - PubMed
    1. Tabuchi T, Ito Y, Ioka A, Miyashiro I, Tsukuma H. Incidence of metachronous second primary cancers in Osaka and Japan: Update of analyses using population-based cancer registry data. Cancer Sci. 2012;103:1111–1120. doi: 10.1111/j.1349-7006.2012.02254.x. - DOI - PMC - PubMed

LinkOut - more resources