Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 19;9(9):2824-2828.
doi: 10.1016/j.ekir.2024.06.022. eCollection 2024 Sep.

Certain Red Yeast Rice Supplements in Japan Cause Acute Tubulointerstitial Injury

Yusuke Murata  1 , Seiichiro Hemmi  1 , Yurie Akiya  1 , Kota Miyasato  1 , Hiroki Kobayashi  1 , Takashi Maruyama  1 , Masanori Abe  1
Affiliations

Certain Red Yeast Rice Supplements in Japan Cause Acute Tubulointerstitial Injury

Yusuke Murata et al. Kidney Int Rep. .
No abstract available

Keywords: Fanconi syndrome; acute kidney injury; acute tubulointerstitial nephritis; red yeast rice.

PubMed Disclaimer

Figures

Figure 1
Figure 1
In case 1, the photomicrographs of renal biopsy revealed flattened proximal tubular cells, loss of the brush border, and sloughing of proximal tubular cells; (a) periodic acid-Schiff staining, ×200; (b) periodic acid-methenamine-silver staining, ×400. (c) Masson trichrome staining revealed mild interstitial fibrosis, ×200. Photomicrographs of renal biopsy from case 2 (d) show several inflammatory cells in the tubulointerstitium. We observed fibrosis and atrophic proximal tubules, as indicated by periodic acid-Schiff staining, ×200. (e) There was no mesangial proliferation, stromal expansion, or thickening of basement membrane. There was a diffuse, mild expansion of mesangial matrix in the glomerulus, as indicated by periodic acid-Schiff staining, ×400. (f) Masson trichrome staining revealed the presence of interstitial fibrosis, ×200. In case 3, we observed shedding and regeneration of renal tubular epithelium in the photomicrographs of renal biopsy. (g) Periodic acid-Schiff, ×400. Masson trichrome staining revealed stromal expansion, fibrosis, and tubular atrophy (h) ×200, and (i) ×400. (j) Severe infiltration of inflammatory cells locally into the tubulointerstitium (Periodic acid-Schiff staining, ×400).
See this image and copyright information in PMC

References

    1. Endo A., Negishi Y., Iwashita T., Mizukawa K., Hirama M. Biosynthesis of ML-236B (compactin) and monacolin K. J Antibiot (Tokyo) 1985;38:444–448. doi: 10.7164/antibiotics.38.444. - DOI - PubMed
    1. Fukami H., Higa Y., Hisano T., Asano K., Hirata T., Nishibe S. A review of red yeast rice, a traditional fermented food in Japan and East Asia: its characteristic ingredients and application in the maintenance and improvement of health in lipid metabolism and the circulatory system. Molecules. 2021;26:1619. doi: 10.3390/molecules26061619. - DOI - PMC - PubMed
    1. Muriithi A.K., Leung N., Valeri A.M., et al. Biopsy-proven acute interstitial nephritis, 1993–2011: a case series. Am J Kidney Dis. 2014;64:558–566. doi: 10.1053/j.ajkd.2014.04.027. - DOI - PubMed
    1. Praga M., González E. Acute interstitial nephritis. Kidney Int. 2010;77:956–961. doi: 10.1038/ki.2010.89. - DOI - PubMed
    1. Xiong Z., Cao X., Wen Q., et al. An overview of the bioactivity of monacolin K / lovastatin. Food Chem Toxicol. 2019;131 doi: 10.1016/j.fct.2019.110585. - DOI - PubMed

LinkOut - more resources