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. 2024 Jul 6;9(9):2759-2766.
doi: 10.1016/j.ekir.2024.07.003. eCollection 2024 Sep.

Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis

Weilin Xiong  1   2 , Qingjun Zhu  3 , Xiaolei Hu  4 , Yehong Yuan  1   2 , Yongwang Zhao  1   2 , Xiaoping Jing  5 , Qingyin Guo  1   2
Affiliations

Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis

Weilin Xiong et al. Kidney Int Rep. .

Abstract

Introduction: Immunoglobulin A vasculitis (IgAV) is related to chronic inflammation; however, little is known about the associations between IgAV and allergic rhinitis (AR) or chronic rhinosinusitis (CRS). We evaluated the relationships among IgAV, AR, and CRS in children.

Methods: The clinical data of children with IgAV who were hospitalized from January to December 2019 were analyzed retrospectively. Four groups were created, the simple AR, simple CRS, AR + CRS, and non-AR or non-CRS groups, to explore the relationships among IgAV, AR, and CRS.

Results: We included 504 children with IgAV; and 357 (70.8%) were combined with AR or CRS, including 51 with simple AR, 70 with simple CRS, and 236 with AR + CRS. The incidences of renal involvement and recurrent rash were significantly higher in the simple AR group than in the non-AR or non-CRS group (P < 0.001). The incidences of renal involvement and recurrent rash were significantly higher in the AR + CRS group than in the non-AR or non-CRS group (P < 0.001). The incidences of renal involvement between the simple CRS group and non-AR or non-CRS group did not differ significantly, but that of recurrent rash was significantly higher than that in the other groups (P < 0.001). Age, abdominal pain, recurrent rash, simple AR, and AR combined with CRS were risk factors for renal involvement (all odds ratio [OR] > 1, P < 0.05).

Conclusion: Chronic rhinitis may be related to the pathogenesis of IgAV, and AR or CRS may be the triggering factors of IgAV. AR may be a risk factor for renal involvement and recurrent rash in patients with IgAV.

Keywords: IgA vasculitis; allergic rhinitis; children; chronic rhinosinusitis; retrospective study.

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Figures

None
Graphical abstract
Figure 1
Figure 1
Flow chart of patient screening. AR, allergic rhinitis; CRS, chronic rhinosinusitis; IgAV, IgA vasculitis.
See this image and copyright information in PMC

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