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. 2024 Sep 6;19(1):20240987.
doi: 10.1515/med-2024-0987. eCollection 2024.

The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae

Yi Xu  1 , Xiangyong Fei  2
Affiliations

The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae

Yi Xu et al. Open Med (Wars). .

Abstract

Objective: To explore the relationship between cytokines such as interferon γ (IFN-γ), interleukin-10 (IL-10), and interleukin-6 (IL-6), as well as the severity of the condition, and serum zinc (Zn) and Fe levels in children with Mycoplasma pneumoniae infection.

Methods: A simple random sampling method was used to select 108 children with Mycoplasma pneumoniae infection admitted to the hospital from January to December 2022 as the study subjects. Collect demographic data such as gender, age, and course of disease from all patients, as well as inflammatory cytokines (InCs) such as IFN-γ, IL-10, and IL-6, the severity of the condition, and serum trace element information such as Zn, Fe, calcium (Ca), and potassium (K) from all patients. Spearman correlation analysis was used to examine the relationship between IFN-γ, IL-10, IL-6, severity of illness, and Zn, Fe, Ca, K in children infected with Mycoplasma pneumoniae. Additionally, receiver operating characteristic (ROC) curve analysis was used to test the predictive efficacy of Zn, Fe, Ca, and K on the severity of the patient's condition.

Results: This study included 108 children infected with Mycoplasma pneumoniae, of whom 6 had clinical data missing >10% and were all excluded. Finally, 102 complete clinical data were collected, with a data recovery efficiency of 94.44%. The differences in IFN-γ, IL-10, IL-6 levels, severity of the condition, as well as Zn, Fe, Ca, K levels among children of different ages, disease courses, body mass, and body temperature showed P < 0. 05. Spearman correlation analysis showed that the levels of IFN-γ, IL-10, IL-6, and severity of the condition in children with Mycoplasma pneumoniae infection were negatively correlated with Zn, Fe, Ca, and K (ρ = -0.319 to -0.827, P < 0.05). The ROC curve analysis results indicate that Zn, Fe, Ca, and K can all be used as indicators to predict the severity of the patient's condition (AUC = 0.710-0.759, P < 0.05).

Conclusion: There is a close relationship between InCs and the severity of the condition in children with Mycoplasma pneumoniae and serum trace elements. Therefore, clinical attention should be paid to monitoring the serum trace element levels of children, and reasonable measures should be taken to regulate them to accelerate the progress of disease treatment.

Keywords: Mycoplasma pneumoniae infection; inflammatory cytokines; serum trace elements; severity of the illness.

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Conflict of interest statement

Conflict of interest: The authors state no conflict of interest.

Figures

Figure 1
Figure 1
The histogram of InCs in children with different demographic characteristics: (a) gender, (b) age, (c) disease course, (d) body mass, and (e) body temperature.
Figure 2
Figure 2
The cumulative bar chart of DS in children with different demographic characteristics: (a) gender, (b) age, (c) disease course, (d) body mass, and (e) body temperature.
Figure 3
Figure 3
The histogram of STE in children with different demographic characteristics: (a) gender, (b) age, (c) disease course, (d) body mass, and (e) body temperature.
Figure 4
Figure 4
Correlation heatmap of InCs and DS with STE in MPnI children: (a)–(d) the correlation between IFN-γ and STE, (e)–(h) the correlation between IL-10 and STE, (i)–(l) the correlation between IL-6 and STE, and (m)–(p) the correlation between DS and STE.
Figure 5
Figure 5
ROC curve of STE on DS in children with MPnI.
See this image and copyright information in PMC

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