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Randomized Controlled Trial
. 2024 Sep 13:38:e089.
doi: 10.1590/1807-3107bor-2024.vol38.0089. eCollection 2024.

Impact of L-PRF on pain and healing outcomes in lower third molar surgery: a randomized split-mouth trial

Raissa Pinheiro Moraes  1 , Fábio Wildson Gurgel Costa  1 , Paulo Goberlânio de Barros Silva  1 , Francisco Samuel Rodrigues Carvalho  1 , Jéssica Emanuella Rocha Moura Paz  2 , Gabriel Carvalho Matos  3 , Marcela Lima Gurgel  1 , Edson Luiz Cetira Filho  1 , Eduardo Costa Studart Soares  1
Affiliations
Randomized Controlled Trial

Impact of L-PRF on pain and healing outcomes in lower third molar surgery: a randomized split-mouth trial

Raissa Pinheiro Moraes et al. Braz Oral Res. .

Abstract

This study explored the effects of L-PRF on pain, soft tissue healing, periodontal condition, and post-extraction bone repair of mandibular third molars (3Ms). A randomized, prospective, triple-blind, split-mouth clinical trial was conducted with 34 volunteers. Eligible patients were randomly allocated into two treatments: G1 (without L-PRF), G2 (alveoli filled with L-PRF), in which the removal of bilateral 3Ms was performed at the same surgical time. Outcomes were assessed according to a visual analogue scale (pain), soft tissue scoring system (wound healing), periodontal probing of mandibular second molar. Bone repair was determined by volumetric analysis (ITK-SNAP software) and fractal analysis (ImageJ software). An intention-to-treat approach to Statistical analysis was used. L-PRF reduced pain in the 7-day postoperative follow-up (p = 0.019) and not only improved soft tissue healing after 1 month of follow-up (p = 0.021), but also probing depth (distal face) in 3 months postoperatively (p = 0.011). Significant alveolar reduction occurred in 3 months after surgery in both treatments (p < 0.05), however, this was more significant in G1 (p = 0.016). The fractal dimension showed no statistical differences. L-PRF improved postoperative clinical parameters of pain, soft tissue healing, and periodontal condition, suggesting that it has a beneficial effect on preserving the alveolar ridge and accelerating the initial repair process.

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Conflict of interest statement

Declaration of Interests: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript.

Figures

Figure 1
Figure 1. Alveolar reconstruction using the ITK-SNAP software. A. Sagittal slices; B. Axial slice; C. Coronal slice; D. Three-dimensional reconstruction of alveoli for volume calculation.
Figure 2
Figure 2. Step-by-step analysis of the fractal dimension of the dental alveoli. A. Coronal slice (5-mm thick) of a CBCT scan; B. Delimitation of the region of interest (ROI) C. ROI (dental socket); D. Blurred image with Gaussian filter; E. Image subtraction result; F. – Addition of a gray value threshold of 128; G. Binary image; H. Eroded image; I. Dilated image; J. Skeletonized image.
Figure 3
Figure 3. Flow Diagram Following the CONSORT Statement.
See this image and copyright information in PMC

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