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. 2024 Dec;19(1):2404198.
doi: 10.1080/15592294.2024.2404198. Epub 2024 Sep 18.

Maternal glucose levels and late pregnancy circulating extracellular vesicle and particle miRNAs in the MADRES pregnancy cohort

Elizabeth C Anderson  1 , Helen B Foley  2 , Joshua J Levy  3   4 , Megan E Romano  1 , Jiang Gui  5 , Jessica L Bentz  6 , Luis E Maldonado  2 , Shohreh F Farzan  2 , Theresa M Bastain  2 , Carmen J Marsit  7 , Carrie V Breton  2 , Caitlin G Howe  1
Affiliations

Maternal glucose levels and late pregnancy circulating extracellular vesicle and particle miRNAs in the MADRES pregnancy cohort

Elizabeth C Anderson et al. Epigenetics. 2024 Dec.

Abstract

Maternal hyperglycemia during pregnancy adversely affects maternal and child outcomes. While mechanisms are not fully understood, maternal circulating miRNAs may play a role. We examined whether continuous glucose levels and hyperglycemia subtypes (gestational diabetes, type 2 diabetes, and glucose intolerance) were associated with circulating miRNAs during late pregnancy. Seven miRNAs (hsa-miR-107, hsa-let-7b-5p, hsa-miR-126-3p, hsa-miR-181a-5p, hsa-miR-374a-5p, hsa-miR-382-5p, and hsa-miR-337-5p) were associated (p < 0.05) with either hyperglycemia or continuous glucose levels prior to multiple testing correction. These miRNAs target genes involved in pathways relevant to maternal and child health, including insulin signaling, placental development, energy balance, and appetite regulation.

Keywords: diabetes; glucose; miRNA; pregnancy.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

As the bubble gets bigger, the percentage of target genes increases. The x-axis gives odds ratio from Fisher’s Exact tests.
Figure 1.
Bubble plots showing the top 10 PANTHER pathways for continuous glucose (a) and hyperglycemia subtypes (b). The color of each bubble shows the -log10(P-value) from Fisher’s exact tests. As the color gets darker, the p-value gets smaller. The size of each bubble represents the percentage of genes in each pathway that are identified for the relevant EVP miRnas.
See this image and copyright information in PMC

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