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. 2025 Feb;57(2):603-611.
doi: 10.1007/s11255-024-04209-z. Epub 2024 Sep 19.

Clinical significance of miR-625-5p in patients with sepsis-induced acute kidney injury based on bioinformatics analysis

Baoying Gong #  1 , Jiayi Chen #  2 , Haizhen Yu  3 , Shizhen Li  4
Affiliations

Clinical significance of miR-625-5p in patients with sepsis-induced acute kidney injury based on bioinformatics analysis

Baoying Gong et al. Int Urol Nephrol. 2025 Feb.

Abstract

Purpose: Sepsis often leads to a cluster of life-threatening symptoms affecting multiple organ systems. Among the organs most vulnerable to damage in this state is the kidney; those afflicted with severe sepsis frequently encounter acute kidney injury (AKI). The study was to investigate the diagnostic role of miR-625-5p in sepsis and sepsis-induced acute kidney injury (SI-AKI) and predict the possible pathways of miR-625-5p involved in SI-AKI by bioinformatics method.

Methods: RT-qPCR was used to detect the level of miR-625-5p, and the diagnostic value of miR-625-5p was analyzed using ROC curve. The proliferation and the concentration of inflammatory factors of HK-2 cells induced by LPS were detected by CCK-8 and ELISA. The pathway of miR-625-5p involved in SI-AKI was analyzed by bioinformatics method.

Results: The miR-625-5p expression was downregulated in sepsis as well as SI-AKI and has predictive value for sepsis as well as SI-AKI. In addition, miR-625-5p promoted LPS-induced cell proliferation and inhibited the levels of inflammatory cytokines.

Conclusion: miR-625-5p may be a diagnostic biomarker for SI-AKI.

Keywords: Acute kidney injury; Diagnosis; Sepsis; miR-625-5p.

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Conflict of interest statement

Declarations. Conflict of interest: The authors have no competing interests to declare that are relevant to the content of this article.

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