Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2024 Sep 18;26(1):162.
doi: 10.1186/s13075-024-03396-5.

Pain catastrophizing negatively impacts drug retention rate in patients with Psoriatic Arthritis and axial Spondyloarthritis: results from a 2-years perspective multicenter GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica) study

Damiano Currado  1   2 , Francesca Saracino  1   2 , Piero Ruscitti  3 , Annalisa Marino  1 , Ilenia Pantano  4 , Marta Vomero  1 , Onorina Berardicurti  5   6 , Viktoriya Pavlych  3 , Claudio Di Vico  4 , Francesco Caso  7 , Luisa Costa  7 , Marco Tasso  7 , Federica Camarda  8 , Francesca Misceo  9 , Francesco De Vincenzo  10 , Addolorata Corrado  11 , Luisa Arcarese  1 , Amelia Rigon  1 , Marta Vadacca  1 , Erika Corberi  1   2 , Lyubomyra Kun  1   2 , Francesca Trunfio  1   2 , Andrea Pilato  1   2 , Ludovica Lamberti  1   2 , Francesco Paolo Cantatore  11 , Federico Perosa  9 , Giuliana Guggino  8 , Raffaele Scarpa  7 , Paola Cipriani  3 , Francesco Ciccia  4 , Roberto Giacomelli  1   2 , Luca Navarini  1   2
Affiliations
Observational Study

Pain catastrophizing negatively impacts drug retention rate in patients with Psoriatic Arthritis and axial Spondyloarthritis: results from a 2-years perspective multicenter GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica) study

Damiano Currado et al. Arthritis Res Ther. .

Abstract

Background: Chronic pain and inflammation are common features of rheumatic conditions such as Psoriatic Arthritis (PsA) and Axial Spondyloarthritis (axSpA), often needing prolonged medication treatment for effective management. Maintaining drug retention is essential for both achieving disease control and improving patients' quality of life. This study investigates the influence of pain catastrophizing, a psychological response to pain, on the drug retention rates of PsA and axSpA patients.

Methods: A two-year prospective multicenter observational study involved 135 PsA and 71 axSpA patients. Pain Catastrophizing Scale (PCS) was employed to assess pain catastrophizing. Univariable and multivariable regression analyses were utilized to identify factors associated with drug retention.

Results: In the PsA group, patients early discontinuing therapy showed higher baseline disease activity as well as higher incidence of comorbid fibromyalgia. Notably, pain catastrophizing, specifically the domains of Helplessness, Magnification, and Rumination, were significantly elevated in PsA patients who interrupted the treatment. Multivariable analysis confirmed pain catastrophizing as an independent predictor of drug suspension within two years. In axSpA, drug discontinuation was associated with female gender, shorter disease duration, higher baseline disease activity as well as elevated levels of pain catastrophizing. Univariable analysis supported the role of pain catastrophizing, including its domains, as predictors of treatment interruption. However, limited events in axSpA patients precluded a multivariate analysis.

Conclusion: This prospective study emphasizes the impact of pain catastrophizing on drug retention in patients with PsA and axSpA.

Keywords: Axial Spondyloarthritis; Pain Catastrophizing; Psoriatic Arthritis; Retention Rate.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

    1. Dougados M, Baeten D. Spondyloarthritis. Lancet Lond Engl. 2011;377(9783):2127–37. - PubMed
    1. FitzGerald O, Ogdie A, Chandran V, Coates LC, Kavanaugh A, Tillett W, et al. Psoriatic arthritis Nat Rev Dis Primer. 2021;7(1):59. - PubMed
    1. Haque N, Lories RJ, de Vlam K. Comorbidities associated with psoriatic arthritis compared with non-psoriatic spondyloarthritis: a cross-sectional study. J Rheumatol. 2016;43(2):376–82. - PubMed
    1. Scriffignano S, Perrotta FM, De Socio A, Lubrano E. Role of comorbidities in spondyloarthritis including psoriatic arthritis. Clin Rheumatol. 2019;38(1):3–10. - PubMed
    1. Navarini L, Caso F, Costa L, Currado D, Stola L, Perrotta F, et al. Cardiovascular risk prediction in ankylosing spondylitis: from traditional scores to machine learning assessment. Rheumatol Ther. 2020;7(4):867–82. - PMC - PubMed

Publication types

Substances