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. 2025 Feb 1;110(2):527-531.
doi: 10.3324/haematol.2024.286163.

Susceptibility to BK polyomavirus-associated hemorrhagic cystitis in children undergoing allogeneic transplant

Sheyar Abdullah  1 , Anthony Sabulski  1 , Zahra Hudda  1 , Assem Ziady  1 , Nathan Luebbering  1 , Lucy Giordullo  1 , Elizabeth Odegard  2 , Jason T Blackard  2 , Steve Kleiboeker  3 , Michelle Altrich  3 , Sonata Jodele  1 , Alix E Seif  4 , Stella M Davies  1 , Benjamin L Laskin  5
Affiliations

Susceptibility to BK polyomavirus-associated hemorrhagic cystitis in children undergoing allogeneic transplant

Sheyar Abdullah et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
APOBEC3 deletion polymorphism. (A) A 29.5kb region spanning APOBEC3A and APOBEC3B is removed, forming a hybrid transcript that is distinguishable using a quantitative polymerase chain reaction (PCR) assay, the results of which are shown on a 1.5% agarose gel. The deletion polymorphism is associated with (B) a significant reduction in APOBEC3A expression (P<0.0001) and reduced APOBEC3B expression (P=0.069), and (C) significantly lower levels of plasma APOBEC3B concentration before allogeneic transplant (P=0.04) (P values by Wilcoxon rank-sum).
Figure 2.
Figure 2.
Expression of TLR3 in healthy mouse bladder tissue varies by age. Representative images of immunohistochemistry staining of TLR3 (brown staining indicates TLR3 expression and arrows show submucosa) in 2 neonatal (3 days old), 2 adolescent (21 days old), and 2 adult (4 months old) mice bladders. TLR3 is highly expressed in all layers of the neonatal bladder as demonstrated by the diffuse brown staining in the 3-day old mouse bladders. Expression remains constant in the urothelium but declines with age, as shown by the decreased intensity of the staining in the 21-day old and 4-month old mouse bladders. TLR3 was absent in the lamina propria and muscularis of the 21-day old and 4-month old mice (blue staining with arrows).
See this image and copyright information in PMC

References

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