Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2024 Nov;130(6):1235-1248.
doi: 10.1002/jso.27869. Epub 2024 Sep 19.

The Significance of the Morphological Appearance of Peritoneal Lesions on Imaging in Patients With Peritoneal Malignancies-A Report From Phase 1 of the PRECINCT Study

Aditi Bhatt  1 , Pascal Rousset  2 , Brendan J Moran  3 , Mufaddal Kazi  4 , Dario Baratti  5 , Amine Souadka  6 , Marcello Deraco  5 , Paolo Sammartino  7 , Armando Sardi  8 , Olivier Glehen  9 ; PRECINCT Study Group
Collaborators, Affiliations
Clinical Trial

The Significance of the Morphological Appearance of Peritoneal Lesions on Imaging in Patients With Peritoneal Malignancies-A Report From Phase 1 of the PRECINCT Study

Aditi Bhatt et al. J Surg Oncol. 2024 Nov.

Abstract

Background and aim: This is a report from Phase 1 of the prospective, observational, PRECINCT (Pattern of peritoneal dissemination and REsponse to systemic Chemotherapy IN Common and uncommon peritoneal Tumours) study, in which we studied the incidence of disease at pathological evaluation in different morphological appearances of peritoneal malignancies (PM) on imaging.

Methods: Radiological findings were captured in a specific format that included a description of the morphological appearance of PM and a correlation performed with pathological findings.

Results: In 630 patients enroled at seven centres (September 2022-December 2023), 24 morphological terms were used. Among prespecified terms (N = 8 used in 6350 [92.2%] regions), scalloping was pathologically positive in 93.5%, confluent disease in 78.8%, tumour nodules in 69.6%, thickening in 66.1%, infiltration in 56.3%. Among unspecified appearances (N = 16) for 540 (7.8%) regions, 'enhancement' was positive in 41.5%, micronodules in 65.3% and nodularity in 60.2%. Hierarchal clustering placed gastric cancer and rare tumours together and colorectal cancer, ovarian cancer and peritoneal mesothelioma in one cluster.

Conclusions: The incidence of disease at pathological evaluation for most morphological appearances was high (> 50%). Morphological description should be provided in routine radiology reports. A set of standardized terms with their description should be developed by a consensus among experienced radiologists.

Keywords: MRI peritoneum; cytoreductive surgery; imaging; morphological apperance; peritoneal malignancy.

PubMed Disclaimer

References

    1. A. H. Mirnezami, B. J. Moran, and T. D. Cecil, “Sugarbaker Procedure for Pseudomyxoma Peritonei,” Techniques in Coloproctology 13 (2009): 373–374, https://doi.org/10.1007/s10151-009-0513-3.
    1. C. N. Lin, W. S. Huang, T. H. Huang, et al., “Adding Value of MRI over CT in Predicting Peritoneal Cancer Index and Completeness of Cytoreduction,” Diagnostics 11, no. 4 (2021): 674, https://doi.org/10.3390/diagnostics11040674.
    1. S. A. S. Salo, E. Lantto, E. Robinson, et al., “Prognostic Role of Radiological Peritoneal Cancer Index in Malignant Peritoneal Mesothelioma: National Cohort Study,” Scientific Reports 10 (2020): 13257, https://doi.org/10.1038/s41598-020-70044-8.
    1. G. Avesani, M. Arshad, H. Lu, et al., “Radiological Assessment of Peritoneal Cancer Index on Preoperative CT in Ovarian Cancer Is Related to Surgical Outcome and Survival,” La Radiologia Medica 125, no. 8 (August 2020): 770–776, https://doi.org/10.1007/s11547-020-01170-6.
    1. K. Flicek, A. Ashfaq, C. D. Johnson, C. Menias, S. Bagaria, and N. Wasif, “Correlation of Radiologic With Surgical Peritoneal Cancer Index Scores in Patients With Pseudomyxoma Peritonei and Peritoneal Carcinomatosis: How Well Can We Predict Resectability?,” Journal of Gastrointestinal Surgery 20, no. 2 (February 2016): 307–312, https://doi.org/10.1007/s11605-015-2880-6.

LinkOut - more resources