Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 4;54(4):784-791.
doi: 10.55730/1300-0144.5850. eCollection 2024.

Effect of sex-specific abdominal fat tissue composition on WHO/ISUP nuclear grade of clear cell renal cell carcinoma

Eser Bulut  1 , Ali Küpeli  1 , Mehmet Akif Ramazanoğlu  2 , Hasan Rıza Aydin  2 , İbrahim Sibal  2 , Fatih Biçaklioğlu  2 , Fatih Yildirim  2 , Şenol Adanur  3 , Salih Al  3
Affiliations

Effect of sex-specific abdominal fat tissue composition on WHO/ISUP nuclear grade of clear cell renal cell carcinoma

Eser Bulut et al. Turk J Med Sci. .

Abstract

Background/aim: To investigate the relationship between sex-related visceral obesity and WHO/ISUP nuclear grade in clear cell renal cell carcinoma (ccRCC).

Materials and methods: Between January 2018 and June 2022, 95 patients (56 men and 39 women) with pathologically proven ccRCC who underwent abdominal computed tomography examination were retrospectively examined. The patients were classified into two groups: low- and high-WHO/ISUP nuclear grade ccRCC (n = 58 and n = 37), respectively. Patient height, weight, body mass index (BMI), sex, age, subcutaneous fat area (SFA), visceral fat area (VFA), total fat area (TFA), and percentage of visceral fat (VF%) were recorded for the two groups.

Results: No significant differences were found in age, BMI, SFA, or TFA, but VFA and VF% were significantly higher in the high-grade patient group. In males, maximal tumor diameter (MTD) (67.8% sensitivity and 76.9% specificity) had the highest area under the curve (AUC), while in females, VF% (70.0% sensitivity and 73.7% specificity) had the highest AUC. VF% revealed an odds ratio (OR) of 1.09 in females with high-grade ccRCC, and in males, MTD was an independent predictor of ccRCC with an OR of 1.03.

Conclusions: Sex-related body fat tissue, including VFA and VF%, could be used for estimating WHO/ISUP nuclear grade in patients with ccRCC, especially in females.

Keywords: Clear cell carcinoma; computed tomography; neoplasm grading; obesity; renal cell carcinoma.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Automatic calculation of visceral and subcutaneous fatty tissue in the range of −150 and −30 HU on the CT image in the axial plane at the level of the umbilicus.
Figure 2
Figure 2
44-year-old man with right-sided clear cell renal cell carcinoma. Contrast enhanced CT (a) shows a tumor (arrow) in the right kidney with a VF% of 57.2% (b). Histologic photomicrograph confirms WHO/ISUP nuclear grade IV ccRCC on high-power (400×; hematoxylin-eosin stain) magnification (c).
Figure 3
Figure 3
49-year-old man with right-sided clear cell renal cell carcinoma. Contrast enhanced CT (a) shows a tumor (arrow) in the right kidney with a VF% of 39.2% (b). Histologic photomicrograph confirms WHO/ISUP nuclear grade I ccRCC on high-power (400×; hematoxylin-eosin stain) magnification (c).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Medina-Rico M, López-Ramos H, Lobo M, Romo J, Prada JG. Epidemiology of renal cancer in developing countries: Review of the literature. Canadian Urological Association Journal. 2018;12(3):E154–E162. doi: 10.5489/cuaj.4464. - DOI - PMC - PubMed
    1. Muglia VF, Prando A. Renal cell carcinoma: Histological classification and correlation with imaging findings. Radiologia Brasileira. 2015;48(3):166–74. doi: 10.1590/0100-3984.2013.1927. - DOI - PMC - PubMed
    1. Mattila KE, Vainio P, Jaakkola PM. Prognostic factors for localized clear cell renal cell carcinoma and their application in adjuvant therapy. Cancers. 2022;14(1):239. doi: 10.3390/cancers14010239. - DOI - PMC - PubMed
    1. Mancini V, Battaglia M, Ditonno P, Palazzo S, Lastilla G, et al. Current insights in renal cell cancer pathology. Journal of Urologic Oncology. 2008;26(3):225–238. doi: 10.1016/j.urolonc.2007.05.017. - DOI - PubMed
    1. Browning L, Colling R, Verrill C. WHO/ISUP grading of clear cell renal cell carcinoma and papillary renal cell carcinoma; validation of grading on the digital pathology platform and perspectives on reproducibility of grade. Diagnostic Pathology. 2021;16(1):75. doi: 10.1186/s13000-021-01130-2. - DOI - PMC - PubMed

LinkOut - more resources