Incessant Ventricular Tachycardia: An Atypical Presentation of Chronic Eosinophilic Leukemia

Abstract

Hypereosinophilic syndrome comprises a diverse and intricate array of rare disorders, exhibiting clinical manifestations that extend across various medical subspecialties. Within its myeloid form, chronic eosinophilic leukemia represents a rare myeloid malignancy characterized by severe hematological complications and distinctive organ dysfunction, notably affecting the cardiovascular system. This report presents a rare case of chronic eosinophilic leukemia and Loeffler syndrome with an initial presentation of ventricular tachycardia.

Keywords: CHIC2 locus deletion; Loeffler endocarditis; chronic eosinophilic leukemia; hypereosinophilic syndrome; ventricular tachycardia.

Graphical abstract

Figure 1

Electrocardiogram at Presentation Electrocardiogram showing normal sinus rhythm with premature ventricular complex, incomplete right bundle branch block, and nonspecific ST-T abnormalities.

Figure 2

Cardiac Magnetic Resonance Images (A) Steady-state free precession procession 4-chamber image demonstrating right ventricular apical mass (star). (B) Gradient echo short-axis image demonstrating right ventricular mass. Implantable cardioverter-defibrillator lead is noted on the right side. (C) On delayed gadolinium enhancement 4-chamber image, there is diffuse subendocardial fibrosis of the right ventricle (arrow). There is subendocardial fibrosis noted of the left ventricle (arrow). Right ventricular thrombus is noted at the right ventricular apex.