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Editorial
. 2024 Sep 18;14(3):92859.
doi: 10.5500/wjt.v14.i3.92859.

Donor hepatectomy time and liver transplantation outcomes: An opportunity that cannot be dismissed

Francisca Gonzalez Cohens  1 , Fernando M Gonzalez  2
Affiliations
Editorial

Donor hepatectomy time and liver transplantation outcomes: An opportunity that cannot be dismissed

Francisca Gonzalez Cohens et al. World J Transplant. .

Abstract

The probability of developing primary dysfunction (PD) is a function of the probability of ischemia/reperfusion (I/R) injury. The probability of I/R injury in turn, is a function of several donor and transplantation process variables, among which is ischemia time. Custodio et al studied the duration of a special type of warm ischemia and showed, contrary to what is known, that a longer duration is not statistically different from a shorter one in PD development. This finding opens the door to the unforeseen opportunity of training fellows in performing hepatectomies, since the duration will not jeopardize liver transplant outcomes, albeit with some precautions.

Keywords: Cold ischemia; Liver transplantation; Primary dysfunction; Reperfusion; Warm ischemia.

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Conflict of interest statement

Conflict-of-interest statement: All authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Scatter plot of the probability of primary dysfunction against the probability of ischemia-reperfusion injury ischemia/reperfusion (independent variable).
Figure 2
Figure 2
Scatter plot of the probability of ischemia-reperfusion injury ischemia/reperfusion (independent variable) against cold ischemia time from a 50-yr- old donor with (Bin. 1) or without (Bin. 0) high dopamine dose, liver macrosteatosis, and prolonged intensive care unit stay.
See this image and copyright information in PMC

References

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