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. 2024 Sep 5:75:102801.
doi: 10.1016/j.eclinm.2024.102801. eCollection 2024 Sep.

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis - update from 2017 to 2023

Bridget Chukwudile  1 , Daniel Pan  2   3   4   5   6   7 , Luisa Silva  1   3   4 , Mayuri Gogoi  2   3   4 , Amani Al-Oraibi  1   2   3 , Paul Bird  3   8 , Nisha George  2   4 , Hayley A Thompson  9   10 , Rebecca F Baggaley  2   4   11 , Sally Hargreaves  12 , Manish Pareek  2   3   4   5   13 , Laura B Nellums  1   14
Affiliations

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis - update from 2017 to 2023

Bridget Chukwudile et al. EClinicalMedicine. .

Abstract

Background: Antimicrobial resistance (AMR) is a critical global health concern. A previous systematic review showed that migrants in Europe are at increased risk of AMR. Since the COVID-19 pandemic there have been rapid changes in patterns of antibiotic use, AMR, and migration. We aimed to present an updated evidence synthesis on the current distribution of AMR among migrants in Europe.

Methods: We carried out a systematic review and meta-analysis in accordance with PRISMA guidelines (PROSPERO ID: CRD42022343263). We searched databases (MEDLINE, Embase, PubMed and Scopus) from 18 January 2017 until 18 January 2023 to identify primary data from observational studies reporting any laboratory-confirmed AMR among migrants in the European Economic Area (EEA) and European Union-15 (EU-15) countries using over 7 key search terms for migrants and over 70 terms for AMR and countries in Europe. Outcomes were infection with, or colonisation of AMR bacteria. Methodological quality was assessed using Joanna Briggs Institute Critical Appraisal Checklist for Observational Studies. We meta-analysed the pooled-prevalence of infection and/or colonisation of AMR organisms.

Findings: Among 630 articles, 21 observational studies met the inclusion criteria and were included in this review. The pooled prevalence for any detected AMR was 28.0% (95% CI 18.0%-41.0%, I 2 = 100%) compared to a 25.4% seen in the previous review; gram-negative bacteria 31.0% (95% CI 20.0%-44.0%, I 2 = 100%), and methicillin-resistant staphylococcus aureus 10.0% (95% CI 5.0%-16.0%, I 2 = 99%). Drug-resistant bacteria were more prevalent in community settings in large migrant populations (pooled prevalence: 41.0%, 95% CI 24.0%-60.0%, I 2 = 99%) than in hospitals (21.0%, 95% CI 12.0%-32.0%, I 2 = 99%). AMR estimates in 'other' migrants were 32.0%, (95% CI 12.0%-57.0%, I 2 = 100%) and 28.0% (95% CI 18.0%-38.0%, I 2 = 100%) in forced migrants. No firm evidence of AMR acquisition with arrival time or length of stay in the host country was found.

Interpretation: Studies investigating AMR in migrants are highly heterogenous. However, since the COVID-19 pandemic, migrants may be at higher risk of acquiring resistant bacteria, particularly gram-negative bacteria, within community settings such as refugee camps and detention centres in Europe. Our study highlights the importance of infrastructure and hygiene measures within these settings, to mitigate transmission of resistant pathogens. Policy-makers should screen for AMR in migrants prior to departure from countries of origin, where feasible, and upon arrival to a new country to ensure optimal health screening, infection control and effective treatment.

Funding: There was no funding source for this study.

Keywords: Antimicrobial resistance; Bacteria; Europe/EU-15 or EEA; Migrants; Refugees.

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Conflict of interest statement

We declare no competing interests. DP is supported by a NIHR Doctoral Research Fellowship (NIHR302338). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. MP is supported by the NIHR Leicester Biomedical Research Centre (BRC) and NIHR Applied Health Collaboration East Midlands, as well as a NIHR Development and Skills Enhancement Award. SH is funded by the NIHR (NIHR300072), the Academy of Medical Sciences (SBF005l1), La Caixa Foundation (LCF/PR/SP21/52930003), Research England, MRC and WHO.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram, illustrating the flow of studies from identification to inclusion.
Fig. 2
Fig. 2
Distribution of AMR organisms according to migrants region of origin. Abbreviations used: AMR: antimicrobial resistance.
Fig. 3
Fig. 3
Forest plot showing pooled prevalence of AMR among migrants. Abbreviations used: AMR: antimicrobial resistance.
Fig. 4
Fig. 4
Forest plot showing pooled prevalence of AMR in community (A) and hospital (B) settings. Abbreviations used: AMR: antimicrobial resistance.
Fig. 5
Fig. 5
Forest plot showing pooled prevalence of AMR in other migrants (A) and forced migrants (B). Abbreviations used: AMR: antimicrobial resistance.
See this image and copyright information in PMC

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