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Review
. 2024 Jun 30;71(2):114-127.
doi: 10.29262/ram.v71i2.1283.

[Severe asthma: Pathophysiology, diagnosis, and treatment]

[Article in Spanish]
José E Gereda  1   2 , Erika de Arruda-Chaves  1   3 , José Larco  1   4 , Edgar Matos  1   5 , Fernando M Runzer-Colmenares  4   6
Affiliations
Review

[Severe asthma: Pathophysiology, diagnosis, and treatment]

[Article in Spanish]
José E Gereda et al. Rev Alerg Mex. .

Abstract
in English, Spanish

Severe asthma is an entity with a complex diagnosis, requiring an adequate differential diagnosis and identification of endotypes for a correct approach and therapeutic process. In the present review, we show a synthesis of the current literature on the diagnosis, pathophysiology, and management of severe asthma, having critically analyzed the evidence in search engines such as Medline, Scopus, and Embase.

El asma grave es una enfermedad compleja, que requiere un enfoque y diagnóstico diferencial ordenado e identificación de endotipos para el correcto abordaje y tratamiento. El tratamiento farmacológico cuenta cada vez con más moléculas a disposición del personal médico para el control efectivo de los síntomas. Esta revisión muestra una síntesis de la bibliografía actual acerca del diagnóstico, fisiopatología y tratamiento del asma grave, mediante la lectura crítica previa de la evidencia científica en buscadores como Medline, Scopus y Embase.

Keywords: Allergy and immunology; Biological products; Bronchial asthma.

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Conflict of interest statement

Los autores declaramos no tener conflictos de interés.

References

    1. Global Initiative for Ashtma. Global Strategy for Ashtma Management and Prevention. www.ginasthma.org
    1. GEMA 5.2. Guía Española para el Manejo del Asma. Sociedad Española de Neumología y Cirugía Torácica. 2022;
    1. Menzies-Gow A, Moore WC, Wechsler ME. Difficult-to-Control Asthma Management in Adults. J Allergy Clin Immunol Pract 2022; 10 (2): 378-384. doi: 10.1016/j.jaip.2021.12.007
    1. Pizzichini MMM, Cancado JED. Severe asthma phenotyping: does the definition of different phenotypes matter? J Bras Pneumol 2022; 48 (3): e20220176. doi: 10.36416/1806-3756/e20220176
    1. Fahy JV. Type 2 inflammation in asthma--present in most, absent in many. Nat Rev Immunol 2015; 15 (1): 57-65. doi: 10.1038/nri3786

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