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. 2024 Sep 19;10(11):1590-1593.
doi: 10.1001/jamaoncol.2024.4000. Online ahead of print.

Transperineal vs Transrectal Prostate Biopsy-The PREVENT Randomized Clinical Trial

Jim C Hu  1 , Melissa Assel  2 , Mohammad E Allaf  3 , Andrew J Vickers  2 , Behfar Ehdaie  4 , Andrew J Cohen  3 , David A Green  5 , Ahmed Ghazi  3 , Benjamin T Ristau  6 , Keith J Kowalczyk  7 , Arvin K George  3 , Hiten D Patel  8 , Jeffrey S Montgomery  9 , Misop Han  3 , Michael Rezaee  3 , Christian P Pavlovich  3 , Neal A Patel  5 , Ashley E Ross  8 , Shilajit D Kundu  8 , Gerald J Wang  5 , Jonathan E Shoag  10 , Nirmish Singla  3 , Kristian Stensland  9 , Michael A Gorin  11 , Anthony J Schaeffer  8 , Edward M Schaeffer  8
Affiliations

Transperineal vs Transrectal Prostate Biopsy-The PREVENT Randomized Clinical Trial

Jim C Hu et al. JAMA Oncol. .
No abstract available

Plain language summary

This randomized clinical trial compares the effect of transperineal vs transrectal prostate biopsy on infection rates after biopsy.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Vickers reported receiving personal fees from Arctic Partners, receiving royalties from Opko for the 4Kscore test, and having stock options in Opko. Dr George reported receiving personal fees from CIVCO Medical Instruments and BK Medical. Dr Shoag reported receiving grants from the Bristol Myers Squibb Foundation and receiving personal fees from Fortec Medical. Dr Gorin reported receiving personal fees from Perineologic and KOELIS Inc. No other disclosures were reported.

Figures

Figure.
Figure.. Trial Flow Diagram
MRI indicates magnetic resonance imaging.
See this image and copyright information in PMC

References

    1. Hu JC, Assel M, Allaf ME, et al. Transperineal versus transrectal magnetic resonance imaging–targeted and systematic prostate biopsy to prevent infectious complications: the PREVENT randomized trial. Eur Urol. 2024;86(1):61-68. doi: 10.1016/j.eururo.2023.12.015 - DOI - PMC - PubMed
    1. Gandaglia G, Leni R, Bray F, et al. Epidemiology and prevention of prostate cancer. Eur Urol Oncol. 2021;4(6):877-892. doi: 10.1016/j.euo.2021.09.006 - DOI - PubMed
    1. Castellani D, Pirola GM, Law YXT, et al. Infection rate after transperineal prostate biopsy with and without prophylactic antibiotics: results from a systematic review and meta-analysis of comparative studies. J Urol. 2022;207(1):25-34. doi: 10.1097/JU.0000000000002251 - DOI - PubMed
    1. Mian BM, Feustel PJ, Aziz A, et al. Complications following transrectal and transperineal prostate biopsy: results of the ProBE-PC randomized clinical trial. J Urol. 2024;211(2):205-213. doi: 10.1097/JU.0000000000003788 - DOI - PubMed
    1. Liss MA, Ehdaie B, Loeb S, et al. An update of the American Urological Association white paper on the prevention and treatment of the more common complications related to prostate biopsy. J Urol. 2017;198(2):329-334. doi: 10.1016/j.juro.2017.01.103 - DOI - PubMed