KRAS takes the road to destruction

Adrienne D Cox^{1

2

3}, Channing J Der^{2

3}

Affiliations

¹ Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
² Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
³ Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Comment

Adrienne D Cox et al. Science. 2024.

. 2024 Sep 20;385(6715):1274-1275.

doi: 10.1126/science.ads2150. Epub 2024 Sep 19.

Adrienne D Cox^{1

2

3}, Channing J Der^{2

3}

¹ Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
² Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
³ Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Abstract

A single small molecule degrades numerous KRAS variants involved in cancer.

Targeting cancer with small-molecule pan-KRAS degraders.
Popow J, Farnaby W, Gollner A, Kofink C, Fischer G, Wurm M, Zollman D, Wijaya A, Mischerikow N, Hasenoehrl C, Prokofeva P, Arnhof H, Arce-Solano S, Bell S, Boeck G, Diers E, Frost AB, Goodwin-Tindall J, Karolyi-Oezguer J, Khan S, Klawatsch T, Koegl M, Kousek R, Kratochvil B, Kropatsch K, Lauber AA, McLennan R, Olt S, Peter D, Petermann O, Roessler V, Stolt-Bergner P, Strack P, Strauss E, Trainor N, Vetma V, Whitworth C, Zhong S, Quant J, Weinstabl H, Kuster B, Ettmayer P, Ciulli A. Popow J, et al. Science. 2024 Sep 20;385(6715):1338-1347. doi: 10.1126/science.adm8684. Epub 2024 Sep 19. Science. 2024. PMID: 39298590