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. 2024 Dec 2;42(26):126375.
doi: 10.1016/j.vaccine.2024.126375. Epub 2024 Sep 18.

Impact of the 2023/24 autumn-winter COVID-19 seasonal booster campaign in preventing severe COVID-19 cases in Italy (October 2023-March 2024)

E A Fotakis  1 , E Picasso  2 , C Sacco  3 , D Petrone  4 , M Del Manso  4 , A Bella  4 , F Riccardo  4 , A Odone  5 , A Cannone  4 , M Tallon  6 , L De Angelis  7 , A Sciurti  8 , D Cescutti  9 , P Pezzotti  4 , M Fabiani  4 , A Mateo-Urdiales  4 ; Italian Integrated Surveillance of COVID-19 study group and of the Italian COVID-19 Vaccines Registry group
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Free article

Impact of the 2023/24 autumn-winter COVID-19 seasonal booster campaign in preventing severe COVID-19 cases in Italy (October 2023-March 2024)

E A Fotakis et al. Vaccine. .
Free article

Abstract

We assessed the impact of the 2023/2024 COVID-19 vaccination campaign in Italy by estimating the number of averted COVID-19 severe cases (i.e. COVID-19 associated hospitalisations or deaths) between October 2023 and March 2024, in those aged ≥60 years. We estimated that 565 (95 % CI: 497-625) cases, corresponding to 2.1 % (95 % CI: 1.8-2.3) of the expected cases without a vaccination campaign, were averted. We simulated three vaccination coverage scenarios: 50 %, 75 %, 90 % (versus the observed 10.7 %), finding that 9.7 % (95 % CI: 8.5-10.7); 14.5 % (95 % CI: 12.8-16.1); and 17.4 % (95 % CI: 15.3-19.3) of the expected cases would have been averted, respectively.

Keywords: COVID-19; Elderly population; Monovalent XBB-adapted vaccines; SARS-CoV-2; Vaccination impact.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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