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Review
. 2024 Nov;25(6):909-926.
doi: 10.1007/s40257-024-00890-z. Epub 2024 Sep 19.

Chronic Hand Eczema

Affiliations
Review

Chronic Hand Eczema

Elke Weisshaar. Am J Clin Dermatol. 2024 Nov.

Abstract

Chronic hand eczema (CHE) is a complex, challenging, and frequently multifactorial skin disease of the hands. It is very common in the general population, especially in certain professions. When hand eczema (HE) persists for longer than 3 months or has a minimum of two relapses per year after initial manifestation with complete clearance, it is considered chronic. In this case, health-related quality of life and the patient's working life are often impaired. CHE can be considered as an umbrella term because it covers different clinical pictures and etiologies. To date, there is no definite and unique HE classification. Treatment starts with identifying the individual HE etiology paralleled by symptomatic therapy (local and/or systemic and/or ultraviolet phototherapy). Sustainable management of HE requires the identification and avoidance of its triggering factors, from the professional and private environment. This includes ruling out allergic contact dermatitis if any HE persists for more than 3 months despite adequate therapy. Randomized controlled trials investigating the efficacy in HE are lacking for several treatment modalities. Patient education measures of skin protection and prevention complete the multimodal treatment.

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Conflict of interest statement

Elke Weisshaar is an active member of the European and German guideline group on CHE and co-author of the European and German guidelines on HE. The content of this review reflects her active role in writing texts for these two guidelines. Elke Weisshaar treats HE patients sent by the German (Governmental) Statutory Accident Insurance. She initiated and leads a cohort study on optimized diagnostics of eczema-psoriasis of the hands that is supported by the German (Governmental) Statutory Accident Insurance, and serves as a Vice President and board member of the German Society for Occupational Dermatology (ABD). Elke Weisshaar is also Treasurer of the European Society of Contact Dermatitis; has participated in clinical trials on itch and prurigo for Menlo, Kiniksa, TREVI, and Galderma; and has been a consultant for Galderma, Sanofi, and LEO Pharmaceuticals.

Figures

Fig. 1
Fig. 1
21-year-old shopkeeper with chronic hyperkeratotic hand eczema
Fig. 2
Fig. 2
42-year-old physiotherapist with a atopic hand eczema and b atopic eczema on the neck

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