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. 1985 Oct;88(4 Suppl):245S-248S.
doi: 10.1378/chest.88.4_supplement.245s.

Potential role of arachidonic acid metabolites in hypoxic pulmonary vasoconstriction

N F Voelkel, M Morganroth, O C Feddersen

Potential role of arachidonic acid metabolites in hypoxic pulmonary vasoconstriction

N F Voelkel et al. Chest. 1985 Oct.

Abstract

Hypoxic vasoconstriction is important for lung ventilation/perfusion matching. The mechanism of hypoxic vasoconstriction remains elusive. Arachidonic acid is released from hypoxic tissues; possibly vasoconstricting arachidonate metabolites are involved in hypoxic pulmonary vasoconstriction. Data are presented that consider (a) lipoxygenase product(s) as "local," which could be involved in the hypoxia induced pulmonary vasoconstriction.

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