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. 2024 Sep;29(38):2400575.
doi: 10.2807/1560-7917.ES.2024.29.38.2400575.

Orthopoxvirus-specific antibodies wane to undetectable levels 1 year after MVA-BN vaccination of at-risk individuals, the Netherlands, 2022 to 2023

Leanne Pm van Leeuwen  1   2   3 , Marc C Shamier  1   3 , Babs E Verstrepen  1 , Hannelore M Götz  4 , Katharina S Schmitz  1 , Najlae Akhiyate  1 , Koen Wijnans  1 , Susanne Bogers  1 , Martin E van Royen  5 , Eric Cm van Gorp  1   2 , Marion Pg Koopmans  1 , Rory D de Vries  1   6 , Corine H GeurtsvanKessel  1   6 , Luca M Zaeck  1
Affiliations

Orthopoxvirus-specific antibodies wane to undetectable levels 1 year after MVA-BN vaccination of at-risk individuals, the Netherlands, 2022 to 2023

Leanne Pm van Leeuwen et al. Euro Surveill. 2024 Sep.

Abstract

In response to the mpox outbreak in 2022 and 2023, widespread vaccination with modified vaccinia Ankara-Bavarian Nordic (MVA-BN, also known as JYNNEOS or Imvanex) was initiated. Here, we demonstrate that orthopoxvirus-specific binding and MVA-neutralising antibodies waned to undetectable levels 1 year post vaccination in at-risk individuals who received two doses of MVA-BN administered subcutaneously with an interval of 4 weeks, without prior smallpox or mpox vaccination. Continuous surveillance is essential to understand the impact of declining antibody levels.

Keywords: MVA; antibodies; immune response; longevity; monkeypox virus; mpox; orthopoxvirus; vaccination.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Antibody longevity after MVA-BN vaccination in gay, bisexual, or other men who have sex with men and in laboratory workers, the Netherlands, 2022–2023 (n = 118)
Figure 2
Figure 2
Antibody longevity after MVA-BN vaccination in longitudinal serum samples obtained from gay, bisexual, or other men who have sex with men visiting the Centre for Sexual Health in Rotterdam, the Netherlands, January 2022–September 2023 (n = 116 individuals)
See this image and copyright information in PMC

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