Malignant salivary gland tumors of the tongue: A multicenter REFCOR study

Valentine Poissonnet¹, Emmanuelle Uro-Coste², Emilien Chabrillac¹, Anouchka Modesto³, Caroline Even⁴, Nicolas Fakhry⁵, Renaud Garrel⁶, Olivier Malard⁷, Florian Chatelet⁸, Charles Dupin⁹, Franck Jegoux¹⁰, Philippe Schultz¹¹, Dorian Culié¹², Robin Baudouin¹³, Diane Evrard¹⁴, Pierre Ransy¹⁵, Sylvain Morinière¹⁶, Haitham Mirghani¹⁷, François Mouawad¹⁸, Christian Righini¹⁹, Suzy Duflo²⁰, Jean-Paul Marie²¹, Florence Jourdan-Soulier²², Sarah Atallah²³, Esteban Brenet²⁴, Chloé Bertolus²⁵, Philippe Ceruse²⁶, Lionel Ramin²⁷, Xavier Dufour²⁸, Duc Trung Nguyen²⁹, Vianney Bastit³⁰, Bertille Segier³¹, Sébastien Vergez¹

Affiliations

¹ Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Larrey Hospital, Toulouse, France.
² Department of Anatomical Pathology, University Cancer Institute Toulouse, Toulouse, France.
³ Department of Radiation Therapy, University Cancer Institute Toulouse-Oncopole, Toulouse, France.
⁴ Head and Neck Oncology Department, Gustave-Roussy Institute, Villejuif, France.
⁵ Otolaryngology, Head and Neck Surgery Department, University Hospital of Marseille, Marseille, France.
⁶ Otolaryngology, Head and Neck Surgery Department, University Hospital of Montpellier, Montpellier, France.
⁷ Otolaryngology, Head and Neck Surgery Department, University Hospital of Nantes, Nantes, France.
⁸ Head and Neck Surgery Department, AP-HP, Hôpital Lariboisière, INSERM UMR 1153 ECSTRRA Team, Paris, France.
⁹ Department of Radiation Therapy, Bordeaux University Hospital-CHU, Bordeaux, France.
¹⁰ Otolaryngology, Head and Neck Surgery Department, University Hospital of Rennes, Rennes, France.
¹¹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Strasbourg, Strasbourg, France.
¹² Otolaryngology, Head and Neck Surgery Department, Head and Neck University Institute, Nice, France.
¹³ Otolaryngology, Head and Neck Surgery Department, Foch Hospital, Paris, France.
¹⁴ Otolaryngology, Head and Neck Surgery Department, Bichat Hospital, Paris, France.
¹⁵ Head and Neck Surgery Department, CHU Sart Tilman, University Liege, Liege, Belgium.
¹⁶ Otolaryngology, Head and Neck Surgery Department, University Hospital of Tours, Tours, France.
¹⁷ Otolaryngology, Head and Neck Surgery Department, George Pompidou European Hospital, Paris, France.
¹⁸ Otolaryngology, Head and Neck Surgery Department, University Hospital of Lille, Lille, France.
¹⁹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Grenoble, Grenoble, France.
²⁰ Otolaryngology, Head and Neck Surgery Department, University Hospital of Point-à-Pitre, Pointe-a-Pitre, France.
²¹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Rouen, Rouen, France.
²² Department of Anatomical Pathology, Toulon Hospital, Toulon, France.
²³ Head and Neck Surgery Department, Tenon Hospital, APHP, Sorbonne University, Paris, France.
²⁴ Otolaryngology, Head and Neck Surgery Department, University Hospital of Reims, Reims, France.
²⁵ Department of Oral and Maxillo-Facial Surgery, Pitié-Salpêtrière Hospital, APHP, Sorbonne Université, Paris, France.
²⁶ Otolaryngology, Head and Neck Surgery Department, University Hospital of Lyon, Lyon, France.
²⁷ Otolaryngology, Head and Neck Surgery Department, University Hospital of Limoges, Limoges, France.
²⁸ Otolaryngology, Head and Neck Surgery Department, University Hospital of Poitiers, Poitiers, France.
²⁹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Nancy, Nancy, France.
³⁰ Otolaryngology, Head and Neck Surgery Department, University Hospital of Caen, Nancy, France.
³¹ Statistical Department, Institut Claudius Regaud, University Institute of Cancer, Toulouse, France.

PMID: 39301840
DOI: 10.1002/ijc.35167

Multicenter Study

Malignant salivary gland tumors of the tongue: A multicenter REFCOR study

Valentine Poissonnet et al. Int J Cancer. 2025.

. 2025 Jan 15;156(2):310-321.

doi: 10.1002/ijc.35167. Epub 2024 Sep 20.

Authors

Affiliations

¹ Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Larrey Hospital, Toulouse, France.
² Department of Anatomical Pathology, University Cancer Institute Toulouse, Toulouse, France.
³ Department of Radiation Therapy, University Cancer Institute Toulouse-Oncopole, Toulouse, France.
⁴ Head and Neck Oncology Department, Gustave-Roussy Institute, Villejuif, France.
⁵ Otolaryngology, Head and Neck Surgery Department, University Hospital of Marseille, Marseille, France.
⁶ Otolaryngology, Head and Neck Surgery Department, University Hospital of Montpellier, Montpellier, France.
⁷ Otolaryngology, Head and Neck Surgery Department, University Hospital of Nantes, Nantes, France.
⁸ Head and Neck Surgery Department, AP-HP, Hôpital Lariboisière, INSERM UMR 1153 ECSTRRA Team, Paris, France.
⁹ Department of Radiation Therapy, Bordeaux University Hospital-CHU, Bordeaux, France.
¹⁰ Otolaryngology, Head and Neck Surgery Department, University Hospital of Rennes, Rennes, France.
¹¹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Strasbourg, Strasbourg, France.
¹² Otolaryngology, Head and Neck Surgery Department, Head and Neck University Institute, Nice, France.
¹³ Otolaryngology, Head and Neck Surgery Department, Foch Hospital, Paris, France.
¹⁴ Otolaryngology, Head and Neck Surgery Department, Bichat Hospital, Paris, France.
¹⁵ Head and Neck Surgery Department, CHU Sart Tilman, University Liege, Liege, Belgium.
¹⁶ Otolaryngology, Head and Neck Surgery Department, University Hospital of Tours, Tours, France.
¹⁷ Otolaryngology, Head and Neck Surgery Department, George Pompidou European Hospital, Paris, France.
¹⁸ Otolaryngology, Head and Neck Surgery Department, University Hospital of Lille, Lille, France.
¹⁹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Grenoble, Grenoble, France.
²⁰ Otolaryngology, Head and Neck Surgery Department, University Hospital of Point-à-Pitre, Pointe-a-Pitre, France.
²¹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Rouen, Rouen, France.
²² Department of Anatomical Pathology, Toulon Hospital, Toulon, France.
²³ Head and Neck Surgery Department, Tenon Hospital, APHP, Sorbonne University, Paris, France.
²⁴ Otolaryngology, Head and Neck Surgery Department, University Hospital of Reims, Reims, France.
²⁵ Department of Oral and Maxillo-Facial Surgery, Pitié-Salpêtrière Hospital, APHP, Sorbonne Université, Paris, France.
²⁶ Otolaryngology, Head and Neck Surgery Department, University Hospital of Lyon, Lyon, France.
²⁷ Otolaryngology, Head and Neck Surgery Department, University Hospital of Limoges, Limoges, France.
²⁸ Otolaryngology, Head and Neck Surgery Department, University Hospital of Poitiers, Poitiers, France.
²⁹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Nancy, Nancy, France.
³⁰ Otolaryngology, Head and Neck Surgery Department, University Hospital of Caen, Nancy, France.
³¹ Statistical Department, Institut Claudius Regaud, University Institute of Cancer, Toulouse, France.

PMID: 39301840
DOI: 10.1002/ijc.35167

Abstract

Salivary carcinomas of minor salivary glands are very infrequent tumors. When located in the tongue, the therapeutic strategy may comprise upfront surgery, which may be debilitating, and/or (chemo-)radiotherapy. The aim of this study was to identify the prognostic factors of salivary carcinomas of the tongue in a population-based cohort. This retrospective multicentric study, based on the "Réseau d'Expertise Français sur les Cancers ORL Rares" (REFCOR), included all the patients with a salivary carcinoma of the tongue, diagnosed between January 2009 and December 2018. Dubious slides were reviewed by REFCOR expert pathologists to ensure diagnostic accuracy. Treatment was performed in accordance with national REFCOR recommendations. From 28 centers, 103 patients were included in this study. Median age at diagnosis was 63 years, and 60.2% were female. Tumors were adenoid cystic carcinomas (41.7%), mucoepidermoid carcinomas (30.1%), and other adenocarcinomas (28.2%). Primary treatment was surgical for 61.2% of them. Five-year overall survival (OS) and event-free survival (EFS) rates were 84.7% and 38.6%, respectively. In multivariable analysis, EFS was significantly worse in case of nonsurgical treatment, alcohol consumption, and glossotonsillar sulcus involvement. N-positive status was the only significant prognostic factor for OS in multivariable analysis. Salivary carcinomas of the tongue represent a heterogeneous group of rare tumors, with a high risk of recurrence. In this national cohort, surgery was associated with better EFS and N-status was the main independent prognostic factor for OS.

Keywords: base of tongue; carcinoma; minor salivary gland; oncologic outcomes; tongue.

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References

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Malignant salivary gland tumors of the tongue: A multicenter REFCOR study

Affiliations

Malignant salivary gland tumors of the tongue: A multicenter REFCOR study

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms