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. 2024 Nov 1;47(11):2012-2016.
doi: 10.2337/dc24-0534.

Family History of Diabetes and Clinical Characteristics in Children at Diagnosis of Type 1 Diabetes-A Swedish Population-Based Study

Emma Hedlund  1   2 , Jasaman Tojjar  1   3 , Lisa Lilja  4 , Helena Elding Larsson  4   5 , Gun Forsander  6   7 , Johnny Ludvigsson  8   9 , Claude Marcus  10 , Fredrik Norström  11 , Martina Persson  12   13 , Annelie Carlsson  1   4
Affiliations

Family History of Diabetes and Clinical Characteristics in Children at Diagnosis of Type 1 Diabetes-A Swedish Population-Based Study

Emma Hedlund et al. Diabetes Care. .

Abstract

Objective: To compare the prevalence of parental diabetes between children with and without type 1 diabetes (T1D), and to compare clinical characteristics at diagnosis of T1D in children with, versus without, a family history of diabetes.

Research design and methods: Parental diabetes among children with T1D was compared with a general population cohort. Clinical characteristics were compared by family history of diabetes in parents and grandparents of 3,603 children with T1D using relative risk (RR) and ANOVA.

Results: Children with T1D more often had parents with type 2 diabetes (T2D) (RR 1.88; P < 0.001) than did children without diabetes. Children with T1D and a family history of T2D were more likely to be overweight or obese (P = 0.002).

Conclusions: A family history of T2D and being overweight may contribute to increased risk of T1D.

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Conflict of interest statement

Duality of Interest. No potential conflicts of interest relevant to this article were reported.

Figures

None
Graphical abstract
Figure 1
Figure 1
Comparison of first-generation family history of type 1 and T2D between 11- to 13-year-old children with T1D in BDD cohort and 12-year-old children without diabetes in the reference group.
Figure 2
Figure 2
Family history of diabetes in children with T1D, grouped by first- and second-generation relatives, and stratified on sex of the parents and grandparents. Data are presented as n (%). Comparison of both maternal and paternal grandmothers compared with grandfathers also was significantly less common with family history of both T1D (P < 0.01) and T2D (P = 0.001).
See this image and copyright information in PMC

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