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Review
. 2024 Aug-Sep;40(8-9):634-642.
doi: 10.1051/medsci/2024096. Epub 2024 Sep 20.

[Micro-RNAs as biomarkers of radiation-induced injuries]

[Article in French]
Jules Gueguen  1 , Lucie Ancel  1 , Guillaume Thoer  1 , Mohamed Amine Benadjaoud  1 , Stéphane Flamant  1 , Maâmar Souidi  1
Affiliations
Free article
Review

[Micro-RNAs as biomarkers of radiation-induced injuries]

[Article in French]
Jules Gueguen et al. Med Sci (Paris). 2024 Aug-Sep.
Free article

Abstract
in English, French

In the event of a radiological or nuclear emergency following an accident or malicious act, potentially involving many victims, medical care requires the identification and diagnosis of individuals exposed to high doses of ionizing radiation as quickly as possible. While an initial screening can be carried out directly in the field, additional biological in-lab analyses are required to refine the diagnosis and optimize the therapeutic management of victims. The fast and simultaneous management of many patients is limited by currently established techniques. To overcome these constraints, the use of new biomarkers to predict the risk and severity of radiation-induced injuries is under investigation. This synthesis summarizes the latest scientific advances demonstrating the potential of microRNAs as biomarkers of radiationinduced injuries, highlighting their relevance for human health care and radioprotection.

Title: Les micro-ARN comme biomarqueurs des lésions radio-induites.

Abstract: En cas d’urgence radiologique ou nucléaire résultant d’un accident ou d’un acte de malveillance, la prise en charge médicale requiert l’identification et le diagnostic des individus exposés à de fortes doses de rayonnements ionisants le plus rapidement possible. Bien qu’un triage préliminaire puisse être effectué directement sur le terrain, une analyse complémentaire en laboratoire est nécessaire pour affiner le diagnostic. Les techniques actuellement utilisées limitent la prise en charge rapide et simultanée de nombreux patients. Afin de pallier ces contraintes, l’utilisation de nouveaux biomarqueurs pour prédire le risque et la gravité des lésions radio-induites est à l’étude. Dans cette revue, nous abordons le potentiel des micro-ARN comme biomarqueurs pour le pronostic des lésions radio-induites et leur pertinence pour une utilisation en radioprotection chez l’homme.

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References

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