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. 2024 Oct;106(4):560-562.
doi: 10.1016/j.kint.2024.07.024.

Cilastatin, a new therapeutic promise for acute kidney injury

María Ángeles González-Nicolás  1 , Alberto Lázaro  2
Affiliations

Cilastatin, a new therapeutic promise for acute kidney injury

María Ángeles González-Nicolás et al. Kidney Int. 2024 Oct.

Abstract

Acute kidney injury is a devasting clinical syndrome resulting from multiple causes, characterized by an abrupt deterioration of kidney function for which there is no pharmacologic treatment. Cilastatin has demonstrated direct nephroprotective effects in acute kidney injury and now is shown to be effective to specifically target therapeutically loaded nanoparticles to the proximal tubule to treat acute kidney injury.

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