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. 2025 Jan;21(1):1-2.
doi: 10.1038/s41574-024-01042-3.

The glymphatic system as a nexus between obesity and neurological diseases

Bandy Chen  1 , Stephanie Lenck  2   3 , Jean-Leon Thomas  3   4 , Marc Schneeberger  5   6
Affiliations

The glymphatic system as a nexus between obesity and neurological diseases

Bandy Chen et al. Nat Rev Endocrinol. 2025 Jan.

Abstract

Exploring the glymphatic system across neurological and metabolic diseases might help us to better define the link between obesity and neurological disorders. Recent studies have identified metabolic dysfunction as a risk factor for cognitive decline and neurological disorders through disruption of the glymphatic system.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

Figures

Fig. 1 |
Fig. 1 |. Domino effect of cerebral rewiring.
Overnutrition rewires the glymphatic system and leads to a domino effect of circuit malfunctions. The accumulation of cerebral rewiring in multiple systems results in cognitive decline and brain atrophy.
See this image and copyright information in PMC

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