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. 2025 Feb;39(1):85-93.
doi: 10.1007/s10877-024-01220-8. Epub 2024 Sep 21.

Left ventricular end-diastolic pressure response to spinal anaesthesia in euvolaemic vascular surgery patients

Georgia Gkounti  1 , Charalampos Loutradis  2 , Christos Katsioulis  2 , Vasileios Nevras  2 , Myrto Tzimou  2 , Apostolos G Pitoulias  2 , Helena Argiriadou  3 , Georgios Efthimiadis  4 , Georgios A Pitoulias  5
Affiliations

Left ventricular end-diastolic pressure response to spinal anaesthesia in euvolaemic vascular surgery patients

Georgia Gkounti et al. J Clin Monit Comput. 2025 Feb.

Abstract

Purpose: Regional anaesthesia techniques provide highly effective alternative to general anaesthesia. Existing evidence on the effect of spinal anaesthesia (SA) on cardiac diastolic function is scarce. This study aimed to evaluate the effects of a single-injection, low-dose SA on left ventricular end-diastolic pressures (LVEDP) using echocardiography in euvolaemic patients undergoing elective vascular surgery.

Methods: This is a prospective study in adult patients undergoing elective vascular surgery with SA. Patients with contraindications for SA or significant valvular disease were excluded. During patients' evaluations fluid administration was targeted using arterial waveform monitoring. All patients underwent echocardiographic studies before and after SA for the assessment of indices reflective of diastolic function. LVEDP was evaluated using the E/e' ratio. Blood samples were drawn to measure troponin and brain natriuretic peptide (BNP) levels before and after SA.

Results: A total of 62 patients (88.7% males, 71.00 ± 9.42 years) were included in the analysis. In total population, end-diastolic volume (EDV, 147.51 ± 41.36 vs 141.72 ± 40.13 ml; p = 0.044), end-systolic volume (ESV, 69.50 [51.50] vs 65.00 [29.50] ml; p < 0.001) and E/e' ratio significantly decreased (10.80 [4.21] vs. 9.55 [3.91]; p = 0.019). In patients with elevated compared to those with normal LVEDP, an overall improvement in diastolic function was noted. The A increased (- 6.58 ± 11.12 vs. 6.46 ± 16.10; p < 0.001) and E/A decreased (0.02 ± 0.21 vs. - 0.36 ± 0.90; p = 0.004) only in the elevated LVEDP group. Patients with elevated LVEDP had a greater decrease in E/e' compared to those with normal LVEDP (- 0.03 ± 2.39 vs. - 2.27 ± 2.92; p = 0.002).

Conclusion: This study in euvolaemic patients undergoing elective vascular surgery provides evidence that SA improved LVEDP.

Keywords: Elective vascular surgery; Left ventricular diastolic function; Left ventricular end-diastolic pressure; Spinal anaesthesia.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests.

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