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. 2024 Sep 20;14(9):e085082.
doi: 10.1136/bmjopen-2024-085082.

Cohort profile: Rahima Moosa Mother and Child Hospital maternal HIV cohort, Johannesburg, South Africa

Karl-Günter Technau  1 , Mhairi Maskew  2 , Cornelius Nattey  3 , Candice Hwang  3   4 , Nicola van Dongen  1 , Thalia Ferreira Brizido  1 , Amy Wise  1   5
Affiliations

Cohort profile: Rahima Moosa Mother and Child Hospital maternal HIV cohort, Johannesburg, South Africa

Karl-Günter Technau et al. BMJ Open. .

Abstract

Purpose: The Rahima Moosa Mother and Child Hospital (RMMCH) maternal HIV cohort originated from data systems that were developed to support HIV-related birth care and track outcomes of a complete birth cohort of HIV-exposed infants at Rahima Moosa Hospital and their mothers living with HIV.

Participants: Supported by the Empilweni Services and Research Unit, maternal and infant data from 13 654 pregnant women living with HIV who delivered their infants (and a subset also attended antenatal care) were collected at RMMCH in Johannesburg, South Africa since 2013. Maternal data were collected using counsellor-administered interviews and the 2013-2018 subset of this cohort was linked to the National Health Laboratory Services (NHLS) national HIV cohort-a longitudinal cohort of people living with HIV accessing care in the public sector antiretroviral therapy programme in South Africa that can observe national access to HIV care through laboratory testing data.

Findings to date: Topics addressed by the cohort include antenatal care history, HIV treatment exposure, delivery/birth management, prophylaxis and maternal blood results relevant to HIV captured at delivery. The cohort was also one of the first to describe implementation of early infant diagnosis procedures in South Africa including evaluations of novel point-of-care testing strategies demonstrating improvements in uptake of HIV care among infants accessing point-of-care services.

Future plans: Annual linkage of infant delivery and testing data to longitudinal laboratory test data in the NHLS national HIV cohort is planned to allow for analysis of both infant continuity of care outcomes and as well as evaluation of maternal-infant pair treatment and mobility outcomes in the post partum and later period.

Keywords: EPIDEMIOLOGIC STUDIES; HIV and AIDS; Maternal medicine; Paediatric infectious disease & immunisation.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1. CD4 count category at entry to antenatal care stratified by calendar year.
See this image and copyright information in PMC

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