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. 2024 Dec;24(12):1467-1509.
doi: 10.1007/s12012-024-09921-x. Epub 2024 Sep 22.

Unveiling the Mechanism of Protective Effects of Tanshinone as a New Fighter Against Cardiovascular Diseases: A Systematic Review

Mohammad Mahdi Dabbaghi #  1 , Hesan Soleimani Roudi #  1 , Rozhan Safaei #  1 , Vafa Baradaran Rahimi  2 , Mohammad Reza Fadaei  3 , Vahid Reza Askari  4
Affiliations

Unveiling the Mechanism of Protective Effects of Tanshinone as a New Fighter Against Cardiovascular Diseases: A Systematic Review

Mohammad Mahdi Dabbaghi et al. Cardiovasc Toxicol. 2024 Dec.

Abstract

Tanshinone, a natural compound found in the roots of Salvia miltiorrhiza, has been shown to possess various pharmacological properties, including anti-inflammatory, antioxidant, and cardiovascular protective effects. This article aims to review the literature on the cardiovascular protective effects of tanshinone and its underlying mechanisms. Tanshinone has been demonstrated to improve cardiac function, reduce oxidative stress, and inhibit inflammation in various animal models of cardiovascular diseases. Additionally, it has been shown to regulate multiple signaling pathways involved in the pathogenesis of cardiovascular diseases, such as the PI3K/AKT, MAPK, and NF-κB pathways. Clinical studies have also suggested that tanshinone may have therapeutic potential for treating cardiovascular diseases. In conclusion, tanshinone has emerged as a promising natural compound with significant cardiovascular protective effects, and further research is warranted to explore its potential clinical applications.

Keywords: Salvia miltiorrhiza; Cardiotoxicity; Cardiovascular disease; Inflammation; Myocardial fibrosis; Tanshinone.

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Conflict of interest statement

Declarations Conflicts of interest The authors declare no competing interests. Ethical Approval This is a review article. Ethical approval is not required for the study.

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