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. 1979 Jun 21;63(3):217-22.
doi: 10.1007/BF00433553.

Failure of MIF-I to affect behavioral responses in patients with Parkinson's diseases under L-dopa therapy

T Caraceni, E A Parati, F Girotti, I Celano, C Frigerio, D Cocchi, E E Müller

Failure of MIF-I to affect behavioral responses in patients with Parkinson's diseases under L-dopa therapy

T Caraceni et al. Psychopharmacology (Berl). .

Abstract

In eight subjects with Parkinson's disease under an optimal daily dose of L-dopa, acute administration of MIF-I (200 mg i.v.) did not ameliorate either the total disability score or the intellectual test PM 38 when evaluated in comparison with the effect induced by acute administration of a placebo. Also concomitant evaluation of the effect of MIF-I on the secretion of anterior pituitary hormones which are under dopaminergic control i.e., growth hormone and prolactin, did not reveal any potentiation of the L-dopa-induced stimulus.

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