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. 2024 Oct 8;60(81):11516-11519.
doi: 10.1039/d4cc01942c.

A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

Yuwei Hu  1   2 , Feng Chen  1   2   3 , Hongfang Lu  1   2   4 , Susi Tan  1   2   4 , Yujie Ke  1   5 , Wei Wei Loh  1 , Eugene Jia Hao Soh  1 , Agarwal Taniya  4 , Tommaso Tabaglio  4 , Dave Keng Boon Wee  4 , Jackie Y Ying  1   2   6
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A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

Yuwei Hu et al. Chem Commun (Camb). .

Abstract

A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.

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