Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug;14(8):2079-2084.
doi: 10.5455/OVJ.2024.v14.i8.37. Epub 2024 Aug 31.

Effect of GnRH treatment as a potential solution for ovarian disorders in dairy cows infected with foot and mouth disease in Indonesian smallholder farms

Joko Susilo  1   2 , Erif Maha Nugraha Setyawan  1 , Slamet Hartanto  3 , Michael Haryadi Wibowo  4 , Agung Budiyanto  1
Affiliations

Effect of GnRH treatment as a potential solution for ovarian disorders in dairy cows infected with foot and mouth disease in Indonesian smallholder farms

Joko Susilo et al. Open Vet J. 2024 Aug.

Abstract

Background: The outbreak of foot and mouth disease (FMD) in Indonesia induces reproductive disorders in dairy cows that lead to economic losses to smallholder dairy farms.

Aim: The study was to assess the influence of FMD on reproductive traits and evaluate the effect of gonadotropin hormone-releasing hormone (GnRH) administrations on the reproductive performance in FMD-infected dairy cows.

Methods: The study was conducted in Jemowo village, Taman Sari sub-district, Boyolali district, Central Java, Indonesia. A total of 155 cows were used to identify the reproductive disorders on FMD-infected dairy cows aged 2-10 years old. Cows were raised in similar conditions and fed diets. A single dose of 2 ml GnRH was injected intramuscularly into 96 ovarian disorder cows. Reproductive performance was measured by service per conception (S/C), conception rate (CR), and pregnancy rate (PR). A descriptive study was conducted to demonstrate the results.

Results: The study showed that 61.9% of FMD-infected cows had reproductive disorders, whereby 53.5% ovarian hypofunction, 4.52% silent heat, 1.94% repeat breeder, 1.29% ovarian atrophy, and 0.65% endometritis. FMD-infected cows injected with GnRH had a 98% reproductive recovery rate. Moreover, the S/C, CR, and PR of cows injected with GnRH were 2.02%, 51%, and 85%.

Conclusion: GnRH administrations enhanced the reproductive traits of FMD-infected dairy cows indicated by the improvement of CR and PR.

Keywords: Dairy cow; Foot and mouth disease; Gonadotropin-releasing hormone; Indonesia; Reproductive disorder.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Fig. 1.
Fig. 1.. Illustration of the study of GnRH injection on reproductive performance in FMD-infected cows.
Fig. 2.
Fig. 2.. Displaying pregnancy test using ultrasound (USG) at 60 days post-AI in FMD-infected cows (Foe: Foetus, Amn: amnion, Utr: Uterine) (a); depicting corpus luteum (CL) at normal oestrus cycle (Cav: luteal cavity, Ov: ovarium) (b).
See this image and copyright information in PMC

References

    1. Adjid R.M.A. Foot and mouth disease: an exotic animal disease that must be alert of entry into Indonesia. Wartazoa. 2020;30(2):61–70.
    1. Ahmed W.M, El-Khadrawy H.H, Abd El-Hamed A.R. Applied investigations on ovarian inactivity in buffaloes. In the Proceeding of Third International Conference of Veterinary Research Division. 2006:1–15.
    1. Ari U.C, Pancarci S.M, Kaçar C, Güngör O, Lehimcioğlu N.C, Öztürkler Y, Yildiz S. Effect of progestagen application during ovsynch protocol on pregnancy rates of lactating-grazing cows. Kafkas Univ. Vet. Fak. 2017;23:319–32.
    1. Ariciniega T.V, Leao I.M.R, Galvan E.A, Cunha T.O, El Azzi M.S, Cook N.B, Martins J.P.N. Effect of a high dose of gonadorelin hydrochloride at the first gonadotropin-releasing hormone of the breeding-Ovsynch of a fertility program on ovulation rate and pregnancies per AI in first-service lactating Holstein cows. J. Dairy Sci. 2020;106(12):9718–9732. - PubMed
    1. Besbaci M, Abdelli A, Minviel J.J, Belabdi I, Kaidi R, Raboisson D. Association of pregnancy per artificial insemination with gonadotropin-releasing hormone and human chorionic gonadotropin administered during the luteal phase after artificial insemination in dairy cows: a meta-analysis. J. Dairy Sci. 2020;103:2006–2018. - PubMed

Substances

LinkOut - more resources