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Review
. 2024 Sep 16:17:3005-3020.
doi: 10.2147/JPR.S467249. eCollection 2024.

Diabetic Neuropathic Pain and Circadian Rhythm: A Future Direction Worthy of Study

Baozhong Yang #  1 , Wei Wei #  1   2 , Jun Fang  1   2 , Yating Xue  1   2 , Jiacheng Wei  1   2
Affiliations
Review

Diabetic Neuropathic Pain and Circadian Rhythm: A Future Direction Worthy of Study

Baozhong Yang et al. J Pain Res. .

Abstract

More than half of people with diabetes experience neuropathic pain. Previous research has shown that diabetes patients' neuropathic pain exhibits a circadian cycle, which is characterized by increased pain sensitivity at night. Additional clinical research has revealed that the standard opioid drugs are ineffective at relieving pain and do not change the circadian rhythm. This article describes diabetic neuropathic pain and circadian rhythms separately, with a comprehensive focus on circadian rhythms. It is hoped that this characteristic of diabetic neuropathic pain can be utilized in the future to obtain more effective treatments for it.

Keywords: chronotherapy; circadian rhythm; diabetic neuropathies; microglia; pain; sex characteristics.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Factors associated with the pathogenesis of diabetic neuropathy. Hyperglycemia, dyslipidemia, and insulin resistance promote the activation of PKC, polyol, and AGE pathways, which ultimately affect mitochondrial function and lead to inflammation.
Figure 2
Figure 2
Causes of circadian rhythms in neuropathic pain.
See this image and copyright information in PMC

References

    1. Jensen TS, Baron R, Haanpää M, et al. A new definition of neuropathic pain. Pain. 2011;152(10):2204–2205. doi:10.1016/j.pain.2011.06.017 - DOI - PubMed
    1. Gilron I, Watson CP, Cahill CM, Moulin DE. Neuropathic pain: a practical guide for the clinician. CMAJ. 2006;175(3):265–275. doi:10.1503/cmaj.060146 - DOI - PMC - PubMed
    1. Breitinger U, Breitinger HG. Excitatory and inhibitory neuronal signaling in inflammatory and diabetic neuropathic pain. Molecul Med. 2023;29(1):53. doi:10.1186/s10020-023-00647-0 - DOI - PMC - PubMed
    1. Bahari Z, Meftahi GH. Spinal α(2) -adrenoceptors and neuropathic pain modulation; therapeutic target. Br J Pharmacol. 2019;176(14):2366–2381. doi:10.1111/bph.14580 - DOI - PMC - PubMed
    1. Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9(th) edition. Diabetes Res Clin Pract. 2019;157:107843. doi:10.1016/j.diabres.2019.107843 - DOI - PubMed

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