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Comment
. 2024 May 16;24(4):289-291.
doi: 10.1177/15357597241253680. eCollection 2024 Jul-Aug.

Linking Respiratory Challenges in KCNQ2 Encephalopathy to "Phox2b" Neurons in the Retrotrapezoid Nucleus

Bin Gu  1
Affiliations
Comment

Linking Respiratory Challenges in KCNQ2 Encephalopathy to "Phox2b" Neurons in the Retrotrapezoid Nucleus

Bin Gu. Epilepsy Curr. .
No abstract available

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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References

    1. Orhan G, Bock M, Schepers D, et al. Dominant-negative effects of KCNQ2 mutations are associated with epileptic encephalopathy. Ann Neurol. 2014;75(3):382–394. doi:10.1002/ana.24080 - PubMed
    1. Varghese N, Moscoso B, Chavez A, et al. KCNQ2/3 gain-of-function variants and cell excitability: differential effects in CA1 versus L2/3 pyramidal neurons. J Neurosci. 2023;43(38):6479–6494. doi:10.1523/jneurosci.0980-23.2023 - PMC - PubMed
    1. Mulkey SB, Ben-Zeev B, Nicolai J, et al. Neonatal nonepileptic myoclonus is a prominent clinical feature of KCNQ2 gain-of-function variants R201C and R201H. Epilepsia. 2017;58(3):436–445. doi:10.1111/epi.13676 - PMC - PubMed
    1. Cardani S, Janes TA, Betzner W, Pagliardini S. Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO2 chemoreflex in rats. eLife. 2024; 13:RP94653. doi: 10.7554/eLife.94653.2. - PMC - PubMed
    1. Soto-Perez J, Cleary CM, Sobrinho CR, et al. Phox2b-expressing neurons contribute to breathing problems in Kcnq2 loss- and gain-of-function encephalopathy models. Nat Commun. 2023;14(1):8059. doi:10.1038/s41467-023-43834-7 - PMC - PubMed

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