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. 2024 Jul-Sep;14(3):162-168.
doi: 10.4103/ijabmr.ijabmr_81_24. Epub 2024 Aug 24.

Correlation of Follicle-stimulating Hormone, Anti-Mullerian Hormone, and Antral Follicle Count with Age in Ovarian Reserve Testing

Subrata Das  1 , Namrata Bhattacharya  1 , Ritu Mahata  1 , Sudip Ghosh  2 , Anindya Sundar Bhar  1 , Pragati Srivastava  1
Affiliations

Correlation of Follicle-stimulating Hormone, Anti-Mullerian Hormone, and Antral Follicle Count with Age in Ovarian Reserve Testing

Subrata Das et al. Int J Appl Basic Med Res. 2024 Jul-Sep.

Abstract

Objective: Ovarian reserve and hence ovarian response has a key role in assisted reproductive technology and predicting response to gonadotrophins in controlled ovarian hyperstimulation. Various tools, namely follicle-stimulating hormone (FSH), anti-Mullerian hormone (AMH), antral follicle count (AFC), estradiol, etc., have been studied to discover the best determinant of ovarian reserve. The aim of our study is to correlate different reproductive hormones with age of women to estimate ovarian reserve and to evaluate reliable marker for aiding infertility treatment.

Materials and methods: It is an observational study performed for 6 months, with 88 women (aged 21-39 years) having a complaint of infertility, enrolled in the infertility clinic of a tertiary care hospital. Baseline scan for AFC was done for every patient and their blood was sent for serum FSH, AMH analysis. Statistical procedures were employed to determine the association between age and reproductive hormones (i.e. FSH and AMH) as independent variables and AFC as a dependent variable.

Results: A strong negative correlation was noted between FSH and AMH and between age and AMH (r = -0.492 and r = -0.498, respectively). A weak negative correlation was seen between AMH and total AFC (r = -0.241). A moderate positive correlation was seen on comparing age and FSH (r = 0.331), whereas no correlation was seen on comparing FSH with AFC and AMH with AFC. The presence of ovarian cyst did not affect AMH or AFC but reduced FSH values significantly.

Conclusion: In the quest to determine a panel test for ovarian reserve testing we conclude, FSH and AFC should perform fairly in poor resource and low socioeconomic setting. The combination of FSH with AMH and AFC might aid in better determination of ovarian reserve in tertiary centers with available resources.

Keywords: Anti-Mullerian hormone; antral follicle count; follicle-stimulating hormones; infertility; ovarian reserve.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Scatter plot of follicle-stimulating hormone (day 2nd/3rd) and anti-Mullerian hormone (day 2nd/3rd) according to the study (n = 88). FSH: Follicle-stimulating hormone, AMH: Anti-Mullerian hormone
See this image and copyright information in PMC

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