Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 2;12(3):46.
doi: 10.3390/medsci12030046.

Survival and Durability of Minimally Invasive Mitral Valve Repair: Insights from Different Repair Techniques

Alessandra Iaccarino  1 , Ilaria Giambuzzi  1 , Denise Galbiati  1 , Enea Cuko  1 , Ginevra Droandi  1 , Sara Forcina  1 , Eraldo Kushta  2 , Alessio Basciu  1 , Alessandro Barbone  1 , Andrea Fumero  1 , Lucia Torracca  1
Affiliations

Survival and Durability of Minimally Invasive Mitral Valve Repair: Insights from Different Repair Techniques

Alessandra Iaccarino et al. Med Sci (Basel). .

Abstract

This study evaluates the long-term outcomes of minimally invasive mitral valve repair (MIMVR) in patients with degenerative mitral regurgitation, focusing on survival, mitral valve repair failure, and re-operation rates. A cohort of patients undergoing three primary repair techniques-quadrangular resection, edge-to-edge repair, and artificial chordae implantation-was analyzed using time-to-event methods. The overall survival rates at 1, 10, and 20 years were high and comparable among the techniques, indicating effective long-term benefits of MIMVR. However, freedom from recurrence of moderate mitral regurgitation (MR) ≥ 2 was significantly higher in the quadrangular resection and edge-to-edge groups compared to the artificial chordae group. No significant differences were observed for recurrent MR ≥ 3. Re-operation rates were low and similar across all techniques, underscoring the durability of MIMVR. Pre-discharge residual MR ≥ 2 was identified as a strong predictor of long-term repair failure. These findings confirm the effectiveness of MIMVR, with all techniques demonstrating excellent long-term survival and durability.

Keywords: artificial chordae; edge-to-edge; mini-thoracotomy mitral valve repair; minimally invasive mitral valve repair; mitral valve repair; quadrangular resection.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
KM of overall death.
Figure 2
Figure 2
KM of recurrent MR ≥ 2.
Figure 3
Figure 3
KM of recurrent MR ≥ 3.
See this image and copyright information in PMC

References

    1. Sá M.P., Jacquemyn X., Erten O., Van den Eynde J., Caldonazo T., Doenst T., Ruhparwar A., Weymann A., de Souza R.O.R.R., Rodriguez R., et al. Long-Term Outcomes of Sternal-Sparing Versus Sternotomy Approaches for Mitral Valve Repair: Meta-Analysis of Reconstructed Time-to-Event Data. Innovations. 2023;18:167–174. doi: 10.1177/15569845231166902. - DOI - PubMed
    1. Carpentier A. Cardiac Valve Surgery—The “French Correction”. J. Thorac. Cardiovasc. Surg. 1983;86:323–337. doi: 10.1016/S0022-5223(19)39144-5. - DOI - PubMed
    1. Mazine A., Friedrich J.O., Nedadur R., Verma S., Ouzounian M., Jüni P., Puskas J.D., Yanagawa B. Systematic Review and Meta-Analysis of Chordal Replacement versus Leaflet Resection for Posterior Mitral Leaflet Prolapse. J. Thorac. Cardiovasc. Surg. 2018;155:120–128.e10. doi: 10.1016/j.jtcvs.2017.07.078. - DOI - PubMed
    1. David T.E. Replacement of Chordae Tendineae with Expanded Polytetrafluoroethylene Sutures. J. Card. Surg. 1989;4:286–290. doi: 10.1111/j.1540-8191.1989.tb00291.x. - DOI - PubMed
    1. von Oppell U.O., Mohr F.W. Chordal Replacement for Both Minimally Invasive and Conventional Mitral Valve Surgery Using Premeasured Gore-Tex Loops. Ann. Thorac. Surg. 2000;70:2166–2168. doi: 10.1016/S0003-4975(00)02047-6. - DOI - PubMed

LinkOut - more resources