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. 1985 Jul-Aug:7 Suppl 3:S411-6.
doi: 10.1093/clinids/7.supplement_3.s411.

Activity of imipenem against Pseudomonas and Bacteroides species

J D Williams

Activity of imipenem against Pseudomonas and Bacteroides species

J D Williams. Rev Infect Dis. 1985 Jul-Aug.

Abstract

The activity of imipenem against Pseudomonas aeruginosa and Bacteroides fragilis in vitro was studied. MICs of imipenem for P. aeruginosa are approximately 2 micrograms/m. Unlike most other beta-lactam antibiotics, imipenem does not show cross-resistance in the presence of intrinsic resistance. Imipenem is a strong inducer of Id beta-lactamase but is stable to hydrolysis by this enzyme. B. fragilis is more susceptible to imipenem than to other beta-lactam antibiotics. The activity of imipenem against B. fragilis is similar to that of metronidazole. The cephalosporinases of B. fragilis do not inactivate imipenem.

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