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. 2024 Sep 23;81(11):1228-1230.
doi: 10.1001/jamaneurol.2024.3162. Online ahead of print.

Four-Repeat Tau Seeding in the Skin of Patients With Progressive Supranuclear Palsy

Ivan Martinez-Valbuena  1   2 , M Carmela Tartaglia  1   2 , Susan H Fox  1 , Anthony E Lang  1   2 , Gabor G Kovacs  1   2
Affiliations

Four-Repeat Tau Seeding in the Skin of Patients With Progressive Supranuclear Palsy

Ivan Martinez-Valbuena et al. JAMA Neurol. .
No abstract available

Plain language summary

This study discusses 4-repeat tau seeding in the skin of patients with progressive supranuclear palsy.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Martinez-Valbuena reported a pending patent for 18/537,455. Dr Tartaglia reported grants from the National Institute of Aging, the Weston Brain Institute, and the Tanenbaum Science in Sport Institute outside the submitted work; consultant fees from Eisai, Lilly, and Novo Nordisk and research funding from Roche. Dr Lang reported grants from the Rossy Foundation during the conduct of the study; in addition, Dr Lang has a patent pending for RT-QuIC methods. Dr Kovacs reported fees from the Rossy Family Foundation Philanthropic during the conduct of the study; personal fees from Parexel, Rossy Family Foundation Philanthropic, and Safra Foundation Philanthropic, and grants from Krembil Foundation, MSA Coalition, the Michael J. Fox Foundation, Parkinson Canada, the National Institutes of Health, Canada Foundation for Innovation, and the Ontario Research Fund outside the submitted work, in addition, Dr Kovacs had a patent with royalties paid for 5G4 Synuclein antibody, Wiley, Cambridge, and Elsevier, and a patent for diagnostic assays for movement disorders pending (18/537,455). No other disclosures were reported.

Figures

Figure.
Figure.. Skin 4-Repeat (4R) Tau Seeding Amplification Assay (SAA)
A, Immunoblot analysis of tau protein using an antibody specific to the N-terminal region (tau 6-18) in representative patients from the postmortem cohort with progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA), and Parkinson disease (PD). B, 4R-tau SAA reaction curves from the skin of representative patients with PSP, PD, and MSA from the postmortem cohort. C, A receiver operating characteristic curve illustrating the sensitivity (87.5%) and specificity (95%) of dermal 4-repeat (4R) tau SAA in diagnosing PSP in living patients. D, 4R-tau SAA reaction curves from cervical skin of representative of patients with PSP, PD, and MSA from the in vivo cohort. Each curve represents the average of quadruplicate measurements, with standard deviation values shown to depict the variability observed in the quadruplicates. The dotted line depicts the threshold for 4R-tau SAA positivity. CBS indicates corticobasal syndrome; HC, healthy controls; kDa, kilodaltons; RFU, relative fluorescence units.
See this image and copyright information in PMC

References

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