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Review
. 2024 Sep-Oct;30(5):357-369.
doi: 10.1097/PPO.0000000000000744.

Advancements in Understanding and Preventing Obesity-Related Colon Cancer

Christine Shieh  1 , Henry J Thompson  2 , Eric McLaughlin  3 , Chien-Wei Chiang  4 , Hisham Hussan
Affiliations
Review

Advancements in Understanding and Preventing Obesity-Related Colon Cancer

Christine Shieh et al. Cancer J. 2024 Sep-Oct.

Abstract

Obesity and colorectal cancer are global public health issues, with the prevalence of both conditions increasing over the last 4 decades. In the United States alone, the prevalence of obesity is greater than 40%, and this percentage is projected to increase past 50% by 2030. This review focuses on understanding the association between obesity and the risk of colorectal cancer while also highlighting hypotheses about molecular mechanisms underlying the link between these disease processes. We also consider whether those linkages can be disrupted via weight loss therapies, including lifestyle modifications, pharmacotherapy, bariatric surgery, and endobariatrics.

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Conflict of interest statement

Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

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