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. 2024 Dec;56(12):906-912.
doi: 10.1055/a-2386-7843. Epub 2024 Sep 23.

Exploring the incidence of dysplasia or adenocarcinoma in early onset Barrett's esophagus

Irma C Noordzij  1   2 , Clément J Huysentruyt  3 , Wouter L Curvers  1 , Gesina van Lijnschoten  3 , Ad A M Masclee  4 , Erik J Schoon  1   5
Affiliations

Exploring the incidence of dysplasia or adenocarcinoma in early onset Barrett's esophagus

Irma C Noordzij et al. Endoscopy. 2024 Dec.

Abstract

Background: Currently data on the risk of progression to and lifetime risk of cancer are not available for patients with young onset Barrett's esophagus (BE). Our aim was to obtain epidemiologic data on the incidence of dysplasia or adenocarcinoma in young onset BE in the Netherlands by collecting data on all histologically confirmed cases over a prolonged period of 25 years between January 1, 1991 and December 31, 2015.

Methods: Data were obtained from the Dutch National Pathology Registry. Patients were included if there was a suspicion of BE visualized in the esophagus during the endoscopic examination in combination with a concordant histologic diagnosis of intestinal metaplasia.

Results: 231 patients with early onset BE were identified (median age 26 years [range 0-29 years]), with 17 progressing to dysplasia (6 prevalent and 11 incident). For the patients with incident dysplasia, the median surveillance time between the diagnosis of early onset BE and diagnosis of dysplasia was 5 years (range 0-16 years). The incidence rate of dysplasia was 7.3 per 1000 person-years. There were three patients who developed adenocarcinoma (1 prevalent and 2 incident), who were diagnosed at ages 28, 35, and 36 years. The incidence rate of adenocarcinoma was 1.3 per 1000 person-years.

Conclusions: In this 25-year period, 231 patients were diagnosed with early onset BE in the Netherlands, with 17 patients progressing to dysplasia and three developing adenocarcinoma. This corresponded to incidence rates of 7.3 per 1000 person-years for dysplasia and 1.3 per 1000 person-years for adenocarcinoma.

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Conflict of interest statement

E.J. Schoon received speakers and consultancy fees from Fujifilm Europe.

Figures

Fig. 1
Fig. 1
Study flowchart showing the inclusion and exclusion of patients to produce the final cohort of 231 patients with endoscopically and histologically confirmed early onset Barrett’s esophagus.
Fig. 2
Fig. 2
Endoscopic view of early onset Barrett’s esophagus with early adenocarcinoma (Prague C3M5 with a Paris type IIA/IIB lesion), taken with a Fujifilm gastroscope (HD EG760) and the linked-color imaging (LCI).
See this image and copyright information in PMC

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