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. 2024 Sep;14(9):e12390.
doi: 10.1002/clt2.12390.

Concurrent validity, cut-offs and ability to change of patient-reported outcome measures for rhinitis and asthma in MASK-air®

Jean Bousquet  1   2   3 , Bernardo Sousa-Pinto  4   5 , Josep M Anto  6   7   8 , Anna Bedbrook  3 , Wienczyslawa Czarlewski  3   9 , Ignacio J Ansotegui  10 , Karl-C Bergmann  1   2 , Fulvio Braido  11 , Luisa Brussino  12   13 , Lorenzo Cecchi  14 , Claudia Chaves Loureiro  15   16 , Alvaro A Cruz  17 , Philippe Devillier  18 , Alessandro Fiocchi  19 , Bilun Gemicioglu  20 , Tari Haahtela  21 , Juan Carlos Ivancevich  22 , Ludger Klimek  23   24 , Marek Kulus  25 , Piotr Kuna  26 , Maciej Kupczyk  26 , Violeta Kvedariene  27   28 , Desiree E Larenas-Linnemann  29 , Gilles Louis  30 , Renaud Louis  31   32 , Michael Makris  33 , Mario Morais-Almeida  34 , Marek Niedoszytko  35 , Ken Ohta  36   37 , Markus Ollert  38   39 , Nikolaos Papadopoulos  40 , Vincenzo Patella  41   42   43 , Benoit Pétré  30 , Oliver Pfaar  44 , Francesca Puggioni  45 , Santiago Quirce  46 , Frederico S Regateiro  47   48   49 , Nicolas Roche  50   51 , Philip W Rouadi  52   53 , Boleslaw Samolinski  54 , Joaquin Sastre  55 , Florence Schleich  31   32 , Nicola Scichilone  56 , Luis Taborda-Barata  57   58 , Sanna Toppila-Salmi  59   60 , Arunas Valiulis  61   62 , Ilgim Vardaloglu Koyuncu  20 , Maria Teresa Ventura  63   64 , Arzu Yorgancioglu  65 , Joao A Fonseca  4   5 , Torsten Zuberbier  1   2
Affiliations

Concurrent validity, cut-offs and ability to change of patient-reported outcome measures for rhinitis and asthma in MASK-air®

Jean Bousquet et al. Clin Transl Allergy. 2024 Sep.

Abstract

Patient-reported outcome measures (PROMs) are used to assess a patient's health status at a particular point in time. They are essential in the development of person-centred care. This paper reviews studies performed on PROMs for assessing AR and asthma control, in particular VAS scales that are included in the app MASK-air® (Mobile Airways Sentinel networK) for asthma and rhinitis. VASs were initially developed on paper and pencil and tested for their criterion validity, cut-offs and responsiveness. Then, a multicentric, multinational, double-blind, placebo-controlled, randomised control trial (DB-PC-RCT) using an electronic VAS form was carried out. Finally, with the development of MASK-air® in 2015, previously validated VAS questions were adapted to the digital format and further methodologic evaluations were performed. VAS for asthma, rhinitis, conjunctivitis, work and EQ-5D are included in the app. Additionally, two control-medication scores for allergic symptoms of asthma (e-DASTHMA) were validated for their criterion validity, cut-offs and responsiveness.

Keywords: EQ‐5D; asthma; digital health; rhinitis; visual analogue scale.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
VAS, RQLQ and TNSS before and after treatment (from 14 ).
FIGURE 2
FIGURE 2
Distribution of GINA control categories relative to VAS levels.
FIGURE 3
FIGURE 3
Correlation between ACT and VAS asthma (SACRA) (from 20 ).
FIGURE 4
FIGURE 4
(A) Evolution of T5SS and VAS global allergy symptoms in patients with intermittent allergic rhinitis treated with desloratadine or placebo. (B) Evolution of T5SS and VAS global allergy symptoms in patients with persistent allergic rhinitis treated with desloratadine or placebo.
FIGURE 5
FIGURE 5
The MASK‐air® app.
FIGURE 6
FIGURE 6
Correlation between VAS asthma and dysponea in two studies on severe asthma (from 31 , 32 ).
FIGURE 7
FIGURE 7
Allergy e‐CSMS compared to VAS work (from 26 ). BR, Brazil; FR, France; GE, Germany; IT, Italy; LT, Lithuania; ME, Mexico; POL,Poland; POR, Portugal; SP, Spain.
FIGURE 8
FIGURE 8
Results between the best performing e‐DASTHMA and comparators (from 48 ).
FIGURE 9
FIGURE 9
Correlation between VAS work and global allergy symptoms (from N = 16,925 days).
FIGURE 10
FIGURE 10
Association of VAS or CSMS with EQ‐5D‐5L domains in a multivariate analysis (from 66 ).
See this image and copyright information in PMC

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